[Term]
id: PR:000016853
name: thioredoxin
def: "A protein that is a translation product of the human TXN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ADF" RELATED []
synonym: "TRX" RELATED Gene-based []
synonym: "TXN" EXACT PRO-short-label [PRO:DNx]
synonym: "Trx" EXACT []
synonym: "SASP" EXACT []
synonym: "TRDX" RELATED Gene-based []
synonym: "TRX1" RELATED Gene-based []
synonym: "Txn1" RELATED Gene-based []
synonym: "ATL-derived factor" EXACT []
synonym: "surface-associated sulphydryl protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P10599-2
name: thioredoxin isoform h2 (human)
def: "A thioredoxin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10599-2." [PRO:DNx, UniProtKB:P10599]
comment: Category=organism-sequence.
synonym: "hTXN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10599-2
is_a: PR:P10599 ! thioredoxin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P10599-1
name: thioredoxin isoform 1 (human)
def: "A thioredoxin isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hTXN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10599-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038812 ! thioredoxin isoform 1

[Term]
id: PR:000045665
name: thioredoxin phosphorylated 1 (human)
def: "A thioredoxin (human) that has been phosphorylated on the residue at the position equivalent to Thr-100 of the amino acid sequence represented by UniProtKB:P10599-1. Example: UniProtKB:P10599-1, Thr-100, MOD:00047." [PMID:20619274, iPTMnet:P10599]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20619274). Status=unreviewed.
synonym: "hTXN/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10599-1, Thr-100, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P10599 ! thioredoxin (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P10599
name: thioredoxin (human)
def: "A thioredoxin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P10599]
comment: Category=organism-gene.
synonym: "TRX" RELATED Gene-based [UniProtKB:P10599]
synonym: "TXN" RELATED Gene-based [UniProtKB:P10599]
synonym: "TRDX" RELATED Gene-based [UniProtKB:P10599]
synonym: "TRX1" RELATED Gene-based [UniProtKB:P10599]
synonym: "hTXN" EXACT PRO-short-label [PRO:DNx]
synonym: "Hom s Trx" EXACT [UniProtKB:P10599]
synonym: "ADF (human)" BROAD [UniProtKB:P10599]
synonym: "SASP (human)" EXACT [UniProtKB:P10599]
synonym: "ATL-derived factor (human)" EXACT [UniProtKB:P10599]
synonym: "surface-associated sulphydryl protein (human)" EXACT [UniProtKB:P10599]
xref: UniProtKB:P10599
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016853 ! thioredoxin
relationship: has_gene_template HGNC:12435 ! TXN (human)

[Term]
id: PR:000049566
name: thioredoxin, initiator methionine removed form (human)
def: "A thioredoxin (human) that has had the initiator methionine removed. UniProtKB:P10599, 2-105." [PRO:DNx, Reactome:R-HSA-66000]
comment: Category=organism-modification.
synonym: "hTXN/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000120005" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P10599, 2-105" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-66000 "PR:000049566 located_in GO:0005829"
xref: Reactome:R-HSA-9617732 "PR:000049566 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P10599 ! thioredoxin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens