[Term]
id: PR:P45352
name: thymidylate synthase (rat)
def: "A thymidylate synthase that is encoded in the genome of rat." [OMA:P45352, PANTHER:PTHR11549:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tyms" RELATED Gene-based [UniProtKB:P45352]
synonym: "rTYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "TS (rat)" EXACT [UniProtKB:P45352]
synonym: "TSase (rat)" EXACT [UniProtKB:P45352]
xref: UniProtKB:P45352
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template RGD:3921 ! Tyms (rat)

[Term]
id: PR:000038714
name: thymidylate synthase isoform 1
def: "A thymidylate synthase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07607-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "TYMS/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000016876 ! thymidylate synthase

[Term]
id: PR:P04818-3
name: thymidylate synthase isoform h3 (human)
def: "A thymidylate synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04818-3." [PRO:DNx, UniProtKB:P04818]
comment: Category=organism-sequence.
synonym: "hTYMS/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "thymidylate synthase isoform delta2+3 (human)" EXACT [UniProtKB:P04818]
xref: UniProtKB:P04818-3
is_a: PR:P04818 ! thymidylate synthase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04818-2
name: thymidylate synthase isoform h2 (human)
def: "A thymidylate synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04818-2." [PRO:DNx, UniProtKB:P04818]
comment: Category=organism-sequence.
synonym: "hTYMS/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "thymidylate synthase isoform delta4 (human)" EXACT [UniProtKB:P04818]
xref: UniProtKB:P04818-2
is_a: PR:P04818 ! thymidylate synthase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04818-1
name: thymidylate synthase isoform h1 (human)
def: "A thymidylate synthase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04818-1." [PRO:DNx, UniProtKB:P04818]
comment: Category=organism-sequence.
synonym: "hTYMS/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04818-1
is_a: PR:P04818 ! thymidylate synthase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P45352-1
name: thymidylate synthase isoform 1 (rat)
def: "A thymidylate synthase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rTYMS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P45352-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038714 ! thymidylate synthase isoform 1

[Term]
id: PR:P0A884
name: thymidylate synthase (Escherichia coli K-12)
def: "A thymidylate synthase that is encoded in the genome of Escherichia coli K-12." [OMA:P0A884, PRO:DNx]
comment: Category=organism-gene.
synonym: "thyA" RELATED Gene-based [UniProtKB:P0A884]
synonym: "b2827" RELATED Gene-based [UniProtKB:P0A884]
synonym: "JW2795" RELATED Gene-based [UniProtKB:P0A884]
synonym: "Ec-TYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "TS (Escherichia coli K-12)" BROAD [UniProtKB:P0A884]
synonym: "TSase (Escherichia coli K-12)" EXACT [UniProtKB:P0A884]
xref: EcoCyc:THYMIDYLATESYN-MONOMER
xref: UniProtKB:P0A884
intersection_of: only_in_taxon NCBITaxon:83333 ! Escherichia coli K-12
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template EcoGene:EG11002 ! thyA (Escherichia coli K-12)

[Term]
id: PR:P07607-1
name: thymidylate synthase isoform 1 (mouse)
def: "A thymidylate synthase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mTYMS/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07607-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038714 ! thymidylate synthase isoform 1

[Term]
id: PR:P12461
name: thymidylate synthase (Candida albicans SC5314)
def: "A thymidylate synthase that is encoded in the genome of Candida albicans SC5314." [OMA:P12461, PRO:DAN]
comment: Category=organism-gene. Requested by=PubChem. Note: Additional NCBIGenes (GeneIDs) listed in the UniProtKB entry have been reviewed and removed by PRO:DAN.
synonym: "TMP1" RELATED Gene-based [UniProtKB:P12461]
synonym: "TSA1" RELATED Gene-based [UniProtKB:P12461]
synonym: "CDC21" RELATED Gene-based [UniProtKB:P12461]
synonym: "Calb-TYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "CaO19.3549" RELATED Gene-based [UniProtKB:P12461]
synonym: "CaO19.11033" RELATED Gene-based [UniProtKB:P12461]
synonym: "CAALFM_C205190WA" RELATED Gene-based [UniProtKB:P12461]
synonym: "TS (Candida albicans SC5314)" EXACT [UniProtKB:P12461]
synonym: "TSase (Candida albicans SC5314)" EXACT [UniProtKB:P12461]
xref: UniProtKB:P12461
intersection_of: only_in_taxon NCBITaxon:237561 ! Candida albicans SC5314
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template NCBIGene:3643463 ! TMP1 (Candida albicans SC5314)

[Term]
id: PR:000016876
name: thymidylate synthase
def: "A protein that is a translation product of the human TYMS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "TS" RELATED Gene-based []
synonym: "TYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "thyA" RELATED [PRO:DNx]
synonym: "TSase" EXACT []
synonym: "OK/SW-cl.29" RELATED Gene-based []
xref: IUPHARobj:2642
is_a: PR:000000001 ! protein

[Term]
id: PR:Q2FYK5
name: thymidylate synthase (Staphylococcus aureus subsp. aureus NCTC 8325)
def: "A thymidylate synthase that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325." [OMA:Q2FYK5, PRO:DNx]
comment: Category=organism-gene.
synonym: "thyA" RELATED Gene-based [UniProtKB:Q2FYK5]
synonym: "TYMS (STAA8)" EXACT PRO-short-label [PRO:DNx]
synonym: "SAOUHSC_01435" RELATED Gene-based [UniProtKB:Q2FYK5]
synonym: "TS (Staphylococcus aureus subsp. aureus NCTC 8325)" EXACT [UniProtKB:Q2FYK5]
synonym: "TSase (Staphylococcus aureus subsp. aureus NCTC 8325)" EXACT [UniProtKB:Q2FYK5]
xref: UniProtKB:Q2FYK5
intersection_of: only_in_taxon NCBITaxon:93061 ! Staphylococcus aureus subsp. aureus NCTC 8325
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template EnsemblBacteria:SAOUHSC_01435 ! thyA (Staphylococcus aureus subsp. aureus NCTC 8325)

[Term]
id: PR:O76511
name: thymidylate synthase (fruit fly)
def: "A thymidylate synthase that is encoded in the genome of fruit fly." [OMA:O76511, PANTHER:PTHR11549:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ts" RELATED Gene-based [UniProtKB:O76511]
synonym: "CG3181" RELATED Gene-based [UniProtKB:O76511]
synonym: "fly-TYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "TS (fruit fly)" EXACT [UniProtKB:O76511]
synonym: "TSase (fruit fly)" EXACT [UniProtKB:O76511]
xref: UniProtKB:O76511
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template FlyBase:FBgn0024920 ! Ts (fruit fly)

[Term]
id: PR:P07607
name: thymidylate synthase (mouse)
def: "A thymidylate synthase that is encoded in the genome of mouse." [OMA:P07607, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tyms" RELATED Gene-based [UniProtKB:P07607]
synonym: "mTYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "TS (mouse)" EXACT [UniProtKB:P07607]
synonym: "TSase (mouse)" EXACT [UniProtKB:P07607]
xref: UniProtKB:P07607
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template MGI:98878 ! Tyms (mouse)

[Term]
id: PR:000049572
name: thymidylate synthase, initiator methionine removed form (human)
def: "A thymidylate synthase (human) that has had the initiator methionine removed. UniProtKB:P04818, 2-313." [PRO:DNx, Reactome:R-HSA-613424, Reactome:R-HSA-73518]
comment: Category=organism-modification.
synonym: "PRO_0000140901" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTYMS/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04818, 2-313" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-73518 "PR:000049572 located_in GO:0005829"
xref: Reactome:R-HSA-613424 "PR:000049572 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P04818 ! thymidylate synthase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04818
name: thymidylate synthase (human)
def: "A thymidylate synthase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04818]
comment: Category=organism-gene.
synonym: "TS" RELATED Gene-based [UniProtKB:P04818]
synonym: "TYMS" RELATED Gene-based [UniProtKB:P04818]
synonym: "hTYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "OK/SW-cl.29" RELATED Gene-based [UniProtKB:P04818]
synonym: "TSase (human)" EXACT [UniProtKB:P04818]
xref: UniProtKB:P04818
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template HGNC:12441 ! TYMS (human)

[Term]
id: PR:000021763
name: thymidylate synthase, initiator methionine removed form
def: "A thymidylate synthase that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "TYMS/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000016876 ! thymidylate synthase
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P06785
name: thymidylate synthase (yeast)
def: "A thymidylate synthase that is encoded in the genome of yeast." [OMA:P06785, PANTHER:PTHR11549:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "CRT9" RELATED Gene-based [UniProtKB:P06785]
synonym: "TMP1" RELATED Gene-based [UniProtKB:P06785]
synonym: "CDC21" RELATED Gene-based [UniProtKB:P06785]
synonym: "yTYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "YOR074C" RELATED Gene-based [UniProtKB:P06785]
synonym: "YOR29-25" RELATED Gene-based [UniProtKB:P06785]
synonym: "TS (yeast)" RELATED [UniProtKB:P06785]
synonym: "TSase (yeast)" EXACT [UniProtKB:P06785]
synonym: "cell division cycle protein 21 (yeast)" EXACT [UniProtKB:P06785]
synonym: "constitutive RNR3 transcription protein 9 (yeast)" EXACT [UniProtKB:P06785]
xref: UniProtKB:P06785
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template SGD:S000005600 ! CDC21 (yeast)

[Term]
id: PR:Q9UTI7
name: probable thymidylate synthase (Schizosaccharomyces pombe 972h-)
def: "A thymidylate synthase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PANTHER:PTHR11549:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "SPAC15E1.04" RELATED Gene-based [UniProtKB:Q9UTI7]
synonym: "Spom972h-TYMS" EXACT PRO-short-label [PRO:DNx]
synonym: "TS (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9UTI7]
synonym: "TSase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9UTI7]
xref: UniProtKB:Q9UTI7
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000016876 ! thymidylate synthase
relationship: has_gene_template PomBase:SPAC15E1.04 ! SPAC15E1.04 (Schizosaccharomyces pombe)