[Term]
id: PR:Q92900-1
name: regulator of nonsense transcripts 1 isoform 1 (human)
def: "A regulator of nonsense transcripts 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hUPF1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92900-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026502 ! regulator of nonsense transcripts 1 isoform 1

[Term]
id: PR:Q92900-2
name: regulator of nonsense transcripts 1 isoform 2 (human)
def: "A regulator of nonsense transcripts 1 isoform 2 that is encoded in the genome of human." [PMID:18423202]
comment: Category=organism-sequence.
synonym: "hUPF1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92900-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026504 ! regulator of nonsense transcripts 1 isoform 2

[Term]
id: PR:000017108
name: regulator of nonsense transcripts 1
def: "A protein that is a translation product of the human UPF1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "UPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "Upf1" EXACT []
synonym: "NORF1" EXACT []
synonym: "RENT1" RELATED Gene-based []
synonym: "KIAA0221" RELATED Gene-based []
synonym: "ATP-dependent helicase RENT1" EXACT []
synonym: "nonsense mRNA reducing factor 1" EXACT []
synonym: "up-frameshift suppressor 1 homolog" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000026504
name: regulator of nonsense transcripts 1 isoform 2
def: "A regulator of nonsense transcripts 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92900-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "UPF1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000017108 ! regulator of nonsense transcripts 1

[Term]
id: PR:Q9EPU0
name: regulator of nonsense transcripts 1 (mouse)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of mouse." [OMA:Q9EPU0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Upf1" RELATED Gene-based [UniProtKB:Q9EPU0]
synonym: "Rent1" RELATED Gene-based [UniProtKB:Q9EPU0]
synonym: "mUPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "mUpf1" EXACT [UniProtKB:Q9EPU0]
synonym: "NORF1 (mouse)" EXACT [UniProtKB:Q9EPU0]
synonym: "ATP-dependent helicase RENT1 (mouse)" EXACT [UniProtKB:Q9EPU0]
synonym: "nonsense mRNA reducing factor 1 (mouse)" EXACT [UniProtKB:Q9EPU0]
synonym: "up-frameshift suppressor 1 homolog (mouse)" EXACT [UniProtKB:Q9EPU0]
xref: UniProtKB:Q9EPU0
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template MGI:107995 ! Upf1 (mouse)

[Term]
id: PR:P30771
name: ATP-dependent helicase NAM7 (yeast)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of yeast." [OMA:P30771, PANTHER:PTHR10887:SF26, PRO:DNx]
comment: Category=organism-gene.
synonym: "IFS2" RELATED Gene-based [UniProtKB:P30771]
synonym: "MOF4" RELATED Gene-based [UniProtKB:P30771]
synonym: "NAM7" RELATED Gene-based [UniProtKB:P30771]
synonym: "UPF1" RELATED Gene-based [UniProtKB:P30771]
synonym: "yUPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "YMR080C" RELATED Gene-based [UniProtKB:P30771]
synonym: "YM9582.05C" RELATED Gene-based [UniProtKB:P30771]
synonym: "up-frameshift suppressor 1 (yeast)" EXACT [UniProtKB:P30771]
synonym: "nonsense-mediated mRNA decay protein 1 (yeast)" EXACT [UniProtKB:P30771]
synonym: "nuclear accommodation of mitochondria 7 protein (yeast)" EXACT [UniProtKB:P30771]
xref: UniProtKB:P30771
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template SGD:S000004685 ! NAM7 (yeast)

[Term]
id: PR:Q9VYS3
name: regulator of nonsense transcripts 1 homolog (fruit fly)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of fruit fly." [OMA:Q9VYS3, PANTHER:PTHR10887:SF26, PRO:DNx]
comment: Category=organism-gene.
synonym: "Upf1" RELATED Gene-based [UniProtKB:Q9VYS3]
synonym: "CG1559" RELATED Gene-based [UniProtKB:Q9VYS3]
synonym: "fly-UPF1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VYS3
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template FlyBase:FBgn0030354 ! Upf1 (fruit fly)

[Term]
id: PR:000026502
name: regulator of nonsense transcripts 1 isoform 1
def: "A regulator of nonsense transcripts 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92900-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "UPF1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000017108 ! regulator of nonsense transcripts 1

[Term]
id: PR:000049622
name: regulator of nonsense transcripts 1 phosphorylated 1 (human)
def: "A regulator of nonsense transcripts 1 (human) that has been post-translationally modified to include phosphoserine at positions 1084, 1089, 1107 and 1127 of the amino acid sequence represented by UniProtKB:Q92900. UniProtKB:Q92900, Ser-1084/Ser-1089/Ser-1107/Ser-1127, MOD:00046." [PRO:DNx, Reactome:R-HSA-927856]
comment: Category=organism-modification.
synonym: "hUPF1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92900, Ser-1084/Ser-1089/Ser-1107/Ser-1127, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-927856 "PR:000049622 located_in GO:0005829"
is_a: PR:Q92900 ! regulator of nonsense transcripts 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q09820
name: ATP-dependent helicase upf1 (Schizosaccharomyces pombe 972h-)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09820, PANTHER:PTHR10887:SF26, PRO:DNx]
comment: Category=organism-gene.
synonym: "upf1" RELATED Gene-based [UniProtKB:Q09820]
synonym: "SPAC16C9.06c" RELATED Gene-based [UniProtKB:Q09820]
synonym: "Spom972h-UPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "up-frameshift suppressor 1 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09820]
synonym: "nonsense-mediated mRNA decay protein upf1 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09820]
synonym: "regulator of nonsense transcripts 1 homolog (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09820]
xref: UniProtKB:Q09820
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template PomBase:SPAC16C9.06c ! upf1 (Schizosaccharomyces pombe)

[Term]
id: PR:O76512
name: regulator of nonsense transcripts 1 (worm)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of worm." [OMA:O76512, PRO:DNx]
comment: Category=organism-gene.
synonym: "smg-2" RELATED Gene-based [UniProtKB:O76512]
synonym: "Y48G8AL.6" RELATED Gene-based [UniProtKB:O76512]
synonym: "UPF1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "ATP-dependent helicase smg-2 (worm)" EXACT [UniProtKB:O76512]
synonym: "nonsense mRNA reducing factor 1 (worm)" EXACT [UniProtKB:O76512]
synonym: "up-frameshift suppressor 1 homolog (worm)" EXACT [UniProtKB:O76512]
xref: UniProtKB:O76512
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template WormBase:WBGene00004880 ! smg-2 (worm)

[Term]
id: PR:Q54I89
name: regulator of nonsense transcripts 1 (Dictyostelium discoideum)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54I89, PANTHER:PTHR10887:SF26, PRO:DNx]
comment: Category=organism-gene.
synonym: "upf1" RELATED Gene-based [UniProtKB:Q54I89]
synonym: "Dicty-UPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0288923" RELATED Gene-based [UniProtKB:Q54I89]
synonym: "up-frameshift suppressor 1 homolog (Dictyostelium discoideum)" EXACT [UniProtKB:Q54I89]
xref: UniProtKB:Q54I89
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template dictyBase:DDB_G0288923 ! upf1 (Dictyostelium discoideum)

[Term]
id: PR:Q92900
name: regulator of nonsense transcripts 1 (human)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q92900]
comment: Category=organism-gene.
synonym: "UPF1" RELATED Gene-based [UniProtKB:Q92900]
synonym: "RENT1" RELATED Gene-based [UniProtKB:Q92900]
synonym: "hUPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "hUpf1" EXACT [UniProtKB:Q92900]
synonym: "KIAA0221" RELATED Gene-based [UniProtKB:Q92900]
synonym: "NORF1 (human)" EXACT [UniProtKB:Q92900]
synonym: "ATP-dependent helicase RENT1 (human)" EXACT [UniProtKB:Q92900]
synonym: "nonsense mRNA reducing factor 1 (human)" EXACT [UniProtKB:Q92900]
synonym: "up-frameshift suppressor 1 homolog (human)" EXACT [UniProtKB:Q92900]
xref: Reactome:R-HSA-927734 "PR:Q92900 located_in GO:0005829"
xref: UniProtKB:Q92900
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template HGNC:9962 ! UPF1 (human)

[Term]
id: PR:Q9FJR0
name: regulator of nonsense transcripts 1 homolog (Arabidopsis thaliana)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9FJR0, PANTHER:PTHR10887:SF26, PRO:DNx]
comment: Category=organism-gene.
synonym: "LBA1" RELATED Gene-based [UniProtKB:Q9FJR0]
synonym: "UPF1" RELATED Gene-based [UniProtKB:Q9FJR0]
synonym: "At-UPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "MQD22.15" RELATED Gene-based [UniProtKB:Q9FJR0]
synonym: "At5g47010" RELATED Gene-based [UniProtKB:Q9FJR0]
synonym: "ATP-dependent helicase UPF1 (Arabidopsis thaliana)" EXACT [UniProtKB:Q9FJR0]
xref: UniProtKB:Q9FJR0
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template Araport:AT5G47010 ! UPF1 (Arabidopsis thaliana)

[Term]
id: PR:Q9EPU0-2
name: regulator of nonsense transcripts 1 isoform 2 (mouse)
def: "A regulator of nonsense transcripts 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mUPF1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EPU0-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026504 ! regulator of nonsense transcripts 1 isoform 2

[Term]
id: PR:Q9EPU0-1
name: regulator of nonsense transcripts 1 isoform 1 (mouse)
def: "A regulator of nonsense transcripts 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mUPF1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EPU0-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026502 ! regulator of nonsense transcripts 1 isoform 1