[Term]
id: PR:Q92900
name: regulator of nonsense transcripts 1 (human)
def: "A regulator of nonsense transcripts 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q92900]
comment: Category=organism-gene.
synonym: "UPF1" RELATED Gene-based [UniProtKB:Q92900]
synonym: "RENT1" RELATED Gene-based [UniProtKB:Q92900]
synonym: "hUPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "hUpf1" EXACT [UniProtKB:Q92900]
synonym: "KIAA0221" RELATED Gene-based [UniProtKB:Q92900]
synonym: "NORF1 (human)" EXACT [UniProtKB:Q92900]
synonym: "ATP-dependent helicase RENT1 (human)" EXACT [UniProtKB:Q92900]
synonym: "nonsense mRNA reducing factor 1 (human)" EXACT [UniProtKB:Q92900]
synonym: "up-frameshift suppressor 1 homolog (human)" EXACT [UniProtKB:Q92900]
xref: Reactome:R-HSA-927734 "PR:Q92900 located_in GO:0005829"
xref: UniProtKB:Q92900
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000017108 ! regulator of nonsense transcripts 1
relationship: has_gene_template HGNC:9962 ! UPF1 (human)

[Term]
id: PR:000049622
name: regulator of nonsense transcripts 1 phosphorylated 1 (human)
def: "A regulator of nonsense transcripts 1 (human) that has been post-translationally modified to include phosphoserine at positions 1084, 1089, 1107 and 1127 of the amino acid sequence represented by UniProtKB:Q92900. UniProtKB:Q92900, Ser-1084/Ser-1089/Ser-1107/Ser-1127, MOD:00046." [PRO:DNx, Reactome:R-HSA-927856]
comment: Category=organism-modification.
synonym: "hUPF1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92900, Ser-1084/Ser-1089/Ser-1107/Ser-1127, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-927856 "PR:000049622 located_in GO:0005829"
is_a: PR:Q92900 ! regulator of nonsense transcripts 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q92900-1
name: regulator of nonsense transcripts 1 isoform 1 (human)
def: "A regulator of nonsense transcripts 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hUPF1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92900-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026502 ! regulator of nonsense transcripts 1 isoform 1

[Term]
id: PR:Q92900-2
name: regulator of nonsense transcripts 1 isoform 2 (human)
def: "A regulator of nonsense transcripts 1 isoform 2 that is encoded in the genome of human." [PMID:18423202]
comment: Category=organism-sequence.
synonym: "hUPF1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92900-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026504 ! regulator of nonsense transcripts 1 isoform 2

[Term]
id: PR:000017108
name: regulator of nonsense transcripts 1
def: "A protein that is a translation product of the human UPF1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "UPF1" EXACT PRO-short-label [PRO:DNx]
synonym: "Upf1" EXACT []
synonym: "NORF1" EXACT []
synonym: "RENT1" RELATED Gene-based []
synonym: "KIAA0221" RELATED Gene-based []
synonym: "ATP-dependent helicase RENT1" EXACT []
synonym: "nonsense mRNA reducing factor 1" EXACT []
synonym: "up-frameshift suppressor 1 homolog" EXACT []
is_a: PR:000000001 ! protein