[Term]
id: PR:000021975
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "p-IRAK1" EXACT []
synonym: "IRAK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 2" EXACT []
is_a: PR:000021971 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine