[Term] id: PR:000027182 name: IRAK4:MYD88:TIRAP:activated TLR4 complex def: "An IRAK4:MYD88:TIRAP:activated TLR complex that contains activated TLR4 receptor." [PMID:12297423, PRO:CNA, PRO:DAN, TLR:AMM] comment: Category=complex. Requested by=TLR. synonym: "IRAK4:MyD88:Mal:activated TLR4" EXACT [] is_a: PR:000027193 ! IRAK4:MYD88:TIRAP:activated TLR complex relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide relationship: has_component PR:000001155 {cardinality="2"} ! Toll-like receptor 4 relationship: has_component PR:000001740 {cardinality="2"} ! myeloid differentiation primary response protein MyD88 relationship: has_component PR:000001751 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein relationship: has_component PR:000001780 ! interleukin-1 receptor-associated kinase 4 relationship: has_component PR:000003296 {cardinality="2"} ! lymphocyte antigen 96 [Term] id: PR:000027183 name: IRAK4:MYD88:TIRAP:activated TLR4 complex (human) def: "An IRAK4:MYD88:TIRAP:activated TLR4 complex that is composed of activated TLR4 receptor, the long isoform of MyD88, Tirap/Mal, and IRAK4 in human." [PMID:12297423, PRO:CNA] comment: Category=organism-complex. synonym: "IRAK4:MyD88:Mal:activated TLR4 (human)" EXACT [] is_a: PR:000027182 ! IRAK4:MYD88:TIRAP:activated TLR4 complex relationship: has_component CHEBI:16412 ! lipopolysaccharide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: has_component PR:000025786 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000025787 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000027184 ! interleukin-1 receptor-associated kinase 4 unmodified form (human) relationship: has_component PR:P58753-1 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human) relationship: has_component PR:Q99836-1 ! myeloid differentiation primary response protein MyD88 isoform 1 (human) [Term] id: PR:000027187 name: IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse) def: "An IRAK4:MYD88:TIRAP:activated TLR4 complex that is composed of activated TLR4 receptor, the long isoform of MyD88, Tirap/Mal, and IRAK4 in mouse." [PMID:12538665, TLR:AMM] comment: Category=organism-complex. Requested by=TLR. synonym: "IRAK4:MyD88:Mal:activated TLR4 (mouse)" EXACT [] is_a: PR:000027182 ! IRAK4:MYD88:TIRAP:activated TLR4 complex relationship: has_component CHEBI:16412 ! lipopolysaccharide relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) relationship: has_component PR:000027181 ! interleukin-1 receptor-associated kinase 4 unmodified form (mouse) relationship: has_component PR:P22366-1 ! myeloid differentiation primary response protein MyD88 isoform 1 (mouse) relationship: has_component PR:Q99JY1 ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse) [Term] id: PR:000027192 name: pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) def: "An IRAK4:MYD88:TIRAP:activated TLR4 complex that is composed of activated TLR4 receptor, MyD88, Tirap/Mal, and phosphorylated IRAK4 in human." [PMID:17141195, PRO:CNA] comment: Category=organism-complex. synonym: "pIRAK4:MyD88:Mal:activated TLR4 (human)" EXACT [Reactome:R-HSA-937048] is_a: PR:000027182 ! IRAK4:MYD88:TIRAP:activated TLR4 complex relationship: has_component CHEBI:16412 ! lipopolysaccharide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: has_component PR:000025786 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000025787 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000027191 ! interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human) relationship: has_component PR:P58753-1 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human) relationship: has_component PR:Q99836-1 ! myeloid differentiation primary response protein MyD88 isoform 1 (human)