[Term]
id: PR:000027208
name: ticam1:ticam2:activated TLR4 complex (human)
def: "A ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:R-HSA-166172]
comment: Category=organism-complex.
synonym: "TRIF:TRAM:activated TLR4 (human)" RELATED [Reactome:R-HSA-166172]
xref: Reactome:R-HSA-166172 "PR:000027208 located_in GO:0010008"
is_a: PR:000027205 ! ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035702 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000027205
name: ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2, and Ticam1." [PMID:17457343, PMID:18222170, TLR:AMM]
comment: Category=complex. Requested by=TLR.
synonym: "TRIF:TRAM:activated TLR4" RELATED [Reactome:R-HSA-166172]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000027207
name: ticam1:ticam2:activated TLR4 complex (mouse)
def: "A ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of mouse." [PMID:14519765, PMID:18222170, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TLR4MD2LPSditt" EXACT [TLR:AMM]
synonym: "TRIF:TRAM:activated TLR4 (mouse)" RELATED [Reactome:R-MMU-166172]
is_a: PR:000027205 ! ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:Q80UF7 ! TIR domain-containing adapter molecule 1 (mouse)
relationship: has_component PR:Q8BJQ4 ! TIR domain-containing adapter molecule 2 (mouse)