[Term]
id: PR:000027495
name: pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
def: "An IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 that has had the IRAK1 subunit phosphorylated by IRAK4 in human." [Reactome:R-HSA-166118]
comment: Category=organism-complex. Requested by=TLR.
synonym: "pIRAK1:IRAK4:MyD88:Mal:activated TLR4 (human)" EXACT [Reactome:R-HSA-166118]
is_a: PR:000027219 ! IRAK1:IRAK4:MYD88:TIRAP:activated TLR4
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027191 {cardinality="4"} ! interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
relationship: has_component PR:000027494 {cardinality="4"} ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
relationship: has_component PR:P58753 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein (human)
relationship: has_component PR:Q99836-1 {cardinality="6"} ! myeloid differentiation primary response protein MyD88 isoform 1 (human)

[Term]
id: PR:000027221
name: pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
def: "An IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 that has had the IRAK1 subunit phosphorylated by IRAK4 in mouse." [PMID:12538665, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "pIRAK1:IRAK4:MyD88:Mal:activated TLR4 (mouse)" EXACT []
is_a: PR:000027219 ! IRAK1:IRAK4:MYD88:TIRAP:activated TLR4
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027178 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
relationship: has_component PR:000027181 ! interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
relationship: has_component PR:P22366-1 ! myeloid differentiation primary response protein MyD88 isoform 1 (mouse)
relationship: has_component PR:Q99JY1 ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse)

[Term]
id: PR:000027220
name: IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
def: "An IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 whose components are encoded in the genome of mouse." [PMID:12538665, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "IRAK1:IRAK4:MyD88:Mal:activated TLR4 (mouse)" EXACT []
is_a: PR:000027219 ! IRAK1:IRAK4:MYD88:TIRAP:activated TLR4
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027179 ! interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
relationship: has_component PR:000027181 ! interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
relationship: has_component PR:P22366-1 ! myeloid differentiation primary response protein MyD88 isoform 1 (mouse)
relationship: has_component PR:Q99JY1 ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse)

[Term]
id: PR:000027219
name: IRAK1:IRAK4:MYD88:TIRAP:activated TLR4
def: "A protein-containing complex that is composed of the activated TLR4 receptor, Mal, MyD88, IRAK1 and IRAK4." [PMID:12538665, TLR:AMM]
comment: Category=complex. Requested by=TLR.
synonym: "IRAK1:IRAK4:MyD88:Mal:activated TLR4" EXACT []
is_a: GO:0032991 ! protein-containing complex