[Term]
id: PR:000027753
name: estrogen receptor isoform 1 phosphorylated 3
def: "An estrogen receptor isoform 1 that has been phosphorylated on a Ser residue in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This phosphorylation site is involved in modulating the expression of genes downregulated by 17-beta-estradiol and 4-Hydroxytamoxifen. Example: UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD, Pfam:PF02159]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine