[Term]
id: PR:000027840
name: cellular tumor antigen p53 isoform 1 sumoylated 1
def: "A cellular tumor antigen p53 isoform 1 that has been sumoylated on a conserved Lys residue located within the regulatory C-terminal domain. While p53 sumoylation at Lys386 inhibits p300 mediated p53 acetylation (at Lys382 and Lys 373), p53 acetylation by p300 remains permissive for subsequent Lys386 sumoylation. Lys386 sumoylated p53 exists as a tetramer in solution. Example: UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD]
comment: Category=modification.
synonym: "TP53/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1
relationship: has_part MOD:01149 ! sumoylated lysine