[Term]
id: PR:000028432
name: TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
def: "A death-inducing signaling complex that is composed of TNF receptor-associated factor 2, initiator methionine removed form (human), tumor necrosis factor (human), receptor-interacting serine/threonine-protein kinase 1 (human), tumor necrosis factor receptor type 1-associated DEATH domain protein (human), and tumor necrosis factor receptor superfamily member 1A, signal peptide removed form (human)." [PRO:DAN, PRO:PDE, Reactome:R-HSA-140946]
comment: Category=organism-complex. Note: The Reactome entry is itself a union of two versions of the complex, one containing TNF(77-233) and the other containing TNF(1-233).
xref: Reactome:R-HSA-140946 "PR:000028432 located_in GO:0005886"
is_a: GO:0031264 ! death-inducing signaling complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000028382 {cardinality="3"} ! TNF receptor-associated factor 2, initiator methionine removed form (human)
relationship: has_component PR:000028386 {cardinality="3"} ! tumor necrosis factor receptor superfamily member 1A, signal peptide removed form (human)
relationship: has_component PR:P01375 {cardinality="3"} ! tumor necrosis factor (human)
relationship: has_component PR:Q13546 {cardinality="1"} ! receptor-interacting serine/threonine-protein kinase 1 (human)
relationship: has_component PR:Q15628 {cardinality="3"} ! tumor necrosis factor receptor type 1-associated DEATH domain protein (human)