[Term] id: PR:000028435 name: TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human) def: "A death-inducing signaling complex that is composed of one molecule of caspase-8 (human), three molecules of TNF receptor-associated factor 2, initiator methionine removed form (human), two molecules of FAS-associated death domain protein (human), one molecule of receptor-interacting serine/threonine-protein kinase 1 (human), and three molecules of tumor necrosis factor receptor type 1-associated DEATH domain protein (human)." [PRO:DAN, PRO:PDE, Reactome:R-HSA-140976] comment: Category=organism-complex. xref: Reactome:R-HSA-140976 "PR:000028435 located_in GO:0005829" is_a: GO:0031264 ! death-inducing signaling complex relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: has_component PR:000028382 {cardinality="1"} ! TNF receptor-associated factor 2, initiator methionine removed form (human) relationship: has_component PR:Q13158 {cardinality="2"} ! FAS-associated death domain protein (human) relationship: has_component PR:Q13546 {cardinality="1"} ! receptor-interacting serine/threonine-protein kinase 1 (human) relationship: has_component PR:Q14790 {cardinality="1"} ! caspase-8 (human) relationship: has_component PR:Q15628 {cardinality="3"} ! tumor necrosis factor receptor type 1-associated DEATH domain protein (human)