[Term]
id: PR:000028437
name: TRAF2:TRADD:RIP1:FADD (human)
def: "A death-inducing signaling complex that is composed of one molecule of TNF receptor-associated factor 2, initiator methionine removed form (human), one molecule of FAS-associated death domain protein (human), one molecule of receptor-interacting serine/threonine-protein kinase 1 (human), and one molecule of tumor necrosis factor receptor type 1-associated DEATH domain protein (human)." [PRO:PDE, Reactome:R-HSA-140977]
comment: Category=organism-complex.
xref: Reactome:R-HSA-140977 "PR:000028437 located_in GO:0005829"
is_a: GO:0031264 ! death-inducing signaling complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000028382 {cardinality="1"} ! TNF receptor-associated factor 2, initiator methionine removed form (human)
relationship: has_component PR:Q13158 {cardinality="1"} ! FAS-associated death domain protein (human)
relationship: has_component PR:Q13546 {cardinality="1"} ! receptor-interacting serine/threonine-protein kinase 1 (human)
relationship: has_component PR:Q15628 {cardinality="1"} ! tumor necrosis factor receptor type 1-associated DEATH domain protein (human)