[Term]
id: PR:000036034
name: IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
def: "An IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF7 (human)" RELATED [Reactome:REACT_27000]
is_a: PR:000036033 ! IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028695 {cardinality="2"} ! serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
relationship: has_component PR:000028704 {cardinality="2"} ! interferon regulatory factor 7 unmodified form (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000036035
name: IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
def: "An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), phosphorylated IKKE, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated IKKE." [Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-IKKE:IRF3" RELATED [Reactome:REACT_27000]
is_a: PR:000028699 ! IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex

[Term]
id: PR:000036036
name: IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
def: "An IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-IKKE:IRF3 (human)" RELATED [Reactome:REACT_27000]
is_a: PR:000036035 ! IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028691 {cardinality="2"} ! inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
relationship: has_component PR:000028702 {cardinality="2"} ! interferon regulatory factor 3 unmodified form (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000036037
name: IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
def: "An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), phosphorylated IKKE, non-phosphorylated IRF7, and TRAF3 linked to Lys-63 polyubiquitin. IRF7 is recruited via phosphorylated IKKE." [Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-IKKE:IRF7" RELATED [Reactome:REACT_27000]
is_a: PR:000028699 ! IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex

[Term]
id: PR:000036030
name: IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
def: "An IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF3 (human)" RELATED [Reactome:REACT_27000]
is_a: PR:000036029 ! IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028695 {cardinality="2"} ! serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
relationship: has_component PR:000028702 {cardinality="2"} ! interferon regulatory factor 3 unmodified form (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000028699
name: IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2, Ticam1, a phosphorylated kinase tbk1 or IKK epsilon and the non-phosphorylated form of IRF3 or IRF7. IRF3 and IRF7 are recruited via phosphorylated tbk1 and IKK epsilon." [Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRAM:TRIF:p-TBK1/p-IKKE:IRF3/IRF7" RELATED [Reactome:REACT_27000]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000036033
name: IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
def: "An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), phosphorylated tbk1, and non-phosphorylated IRF7. IRF7 is recruited via phosphorylated tbk1." [Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF7" RELATED [Reactome:REACT_27000]
is_a: PR:000028699 ! IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex

[Term]
id: PR:000036038
name: IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
def: "An IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-IKKE:IRF7 (human)" RELATED [Reactome:REACT_27000]
is_a: PR:000036037 ! IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028691 {cardinality="2"} ! inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
relationship: has_component PR:000028704 {cardinality="2"} ! interferon regulatory factor 7 unmodified form (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000036029
name: IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
def: "An IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated tbk1, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated tbk1." [Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-poly-Ub-TRAF3:p-TBK1:IRF3" RELATED [Reactome:REACT_27000]
is_a: PR:000028699 ! IRF3/IRF7:p-tbk1/p-IKKE:ticam1:ticam2:activated TLR4 complex