[Term]
id: PR:Q8N726-2
name: tumor suppressor smARF (human)
def: "A CDKN2A gene translation product (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N726-2." [PRO:DAN, UniProtKB:Q8N726]
comment: Category=organism-sequence.
synonym: "hCDKN2A/iso:smARF" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase inhibitor 2A isoform p14ARF (human)" EXACT [UniProtKB:Q8N726]
xref: UniProtKB:Q8N726-2
is_a: PR:000030011 ! CDKN2A gene translation product (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000029097
name: CDKN2A gene translation product
def: "A protein that is a translation product of the human CDKN2A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MTS1" RELATED []
synonym: "CDK4I" EXACT []
synonym: "CDKN2" RELATED []
synonym: "MTS-1" EXACT []
synonym: "CDKN2A" EXACT PRO-short-label [PRO:DNx]
synonym: "p16-INK4" EXACT []
synonym: "p16INK4A" EXACT []
synonym: "p16-INK4a" EXACT []
synonym: "multiple tumor suppressor 1" EXACT []
synonym: "cyclin-dependent kinase inhibitor 2A" EXACT []
synonym: "cyclin-dependent kinase 4 inhibitor A" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8N726-1
name: tumor suppressor ARF (human)
def: "A tumor suppressor ARF that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCDKN2A/iso:ARF" EXACT PRO-short-label [PRO:DNx]
synonym: "CDKN2A isoform 4 (human)" EXACT [PRO:DNx]
synonym: "cyclin-dependent kinase inhibitor 2A isoform 4 (human)" EXACT [UniProtKB:Q8N726]
synonym: "cyclin-dependent kinase inhibitor 2A isoform p19ARF (human)" EXACT [UniProtKB:Q8N726]
xref: UniProtKB:Q8N726-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029146 ! tumor suppressor ARF

[Term]
id: PR:P42771
name: cyclin-dependent kinase inhibitor 2A, isoforms h1/h2/h3/h5 (human)
def: "A cyclin-dependent kinase inhibitor 2A (human), isoforms h1, h2, h3, and h5." [PRO:DAN, UniProtKB:P42771]
comment: Category=organism-seqgroup.
synonym: "hCDKN2A/iso:[1/2/3/5]" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-182578 "PR:P42771 located_in GO:0005829"
xref: UniProtKB:P42771
is_a: PR:000030011 ! CDKN2A gene translation product (human)
union_of: PR:P42771-1 ! cyclin-dependent kinase inhibitor 2A isoform h1 (human)
union_of: PR:P42771-2 ! cyclin-dependent kinase inhibitor 2A isoform h2 (human)
union_of: PR:P42771-3 ! cyclin-dependent kinase inhibitor 2A isoform h3 (human)
union_of: PR:P42771-4 ! cyclin-dependent kinase inhibitor 2A isoform h5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8N726
name: tumor suppressor ARF/smARF (human)
def: "A CDKN2A gene translation product (human), isoforms ARF and smARF." [PRO:DAN, UniProtKB:Q8N726]
comment: Category=organism-seqgroup.
synonym: "hCDKN2A/iso:[ARF/smARF]" EXACT PRO-short-label [PRO:DAN]
synonym: "cyclin-dependent kinase inhibitor 2A isoforms 4/6 (human)" RELATED [PRO:DAN]
xref: Reactome:R-HSA-1629813 "PR:Q8N726 located_in GO:0005654"
xref: Reactome:R-HSA-9645669 "PR:Q8N726 located_in GO:0005829"
xref: Reactome:R-HSA-9645695 "PR:Q8N726 located_in GO:0005759"
xref: UniProtKB:Q8N726
is_a: PR:000030011 ! CDKN2A gene translation product (human)
union_of: PR:Q8N726-1 ! tumor suppressor ARF (human)
union_of: PR:Q8N726-2 ! tumor suppressor smARF (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P42771-4
name: cyclin-dependent kinase inhibitor 2A isoform h5 (human)
def: "A cyclin-dependent kinase inhibitor 2A isoform 5 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCDKN2A/iso:5" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase inhibitor 2A isoform p16gamma (human)" EXACT [UniProtKB:P42771]
xref: UniProtKB:P42771-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029147 ! cyclin-dependent kinase inhibitor 2A isoform 5

[Term]
id: PR:000030011
name: CDKN2A gene translation product (human)
def: "A CDKN2A gene translation product that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-gene.
synonym: "hCDKN2A" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase inhibitor 2A (human)" RELATED [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029097 ! CDKN2A gene translation product
relationship: has_gene_template HGNC:1787 ! CDKN2A (human)

[Term]
id: PR:P42771-1
name: cyclin-dependent kinase inhibitor 2A isoform h1 (human)
def: "A cyclin-dependent kinase inhibitor 2A isoform 1 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCDKN2A/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase inhibitor 2A isoform p16INK4a (human)" EXACT [UniProtKB:P42771]
xref: UniProtKB:P42771-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029143 ! cyclin-dependent kinase inhibitor 2A isoform 1

[Term]
id: PR:P42771-3
name: cyclin-dependent kinase inhibitor 2A isoform h3 (human)
def: "A cyclin-dependent kinase inhibitor 2A isoform 3 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCDKN2A/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase inhibitor 2A isoform p12 (human)" EXACT [UniProtKB:P42771]
xref: UniProtKB:P42771-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029145 ! cyclin-dependent kinase inhibitor 2A isoform 3

[Term]
id: PR:P42771-2
name: cyclin-dependent kinase inhibitor 2A isoform h2 (human)
def: "A cyclin-dependent kinase inhibitor 2A isoform 2 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCDKN2A/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42771-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029144 ! cyclin-dependent kinase inhibitor 2A isoform 2