[Term] id: PR:Q8IWT6 name: volume-regulated anion channel subunit LRRC8A (human) def: "A volume-regulated anion channel subunit LRRC8A that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IWT6] comment: Category=organism-gene. synonym: "LRRC8" RELATED Gene-based [UniProtKB:Q8IWT6] synonym: "LRRC8A" RELATED Gene-based [UniProtKB:Q8IWT6] synonym: "SWELL1" RELATED Gene-based [UniProtKB:Q8IWT6] synonym: "hLRRC8A" EXACT PRO-short-label [PRO:DNx] synonym: "HsLRRC8A" EXACT [UniProtKB:Q8IWT6] synonym: "KIAA1437" RELATED Gene-based [UniProtKB:Q8IWT6] synonym: "UNQ221/PRO247" RELATED Gene-based [UniProtKB:Q8IWT6] synonym: "swelling protein 1 (human)" EXACT [UniProtKB:Q8IWT6] synonym: "leucine-rich repeat-containing protein 8A (human)" EXACT [PRO:DNx] xref: Reactome:R-HSA-8941524 "PR:Q8IWT6 located_in GO:0005886" xref: UniProtKB:Q8IWT6 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000030752 ! volume-regulated anion channel subunit LRRC8A relationship: has_gene_template HGNC:19027 ! LRRC8A (human) [Term] id: PR:000030752 name: volume-regulated anion channel subunit LRRC8A def: "A protein that is a translation product of the human LRRC8A gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "LRRC8" RELATED Gene-based [] synonym: "LRRC8A" EXACT PRO-short-label [PRO:DNx] synonym: "SWELL1" RELATED Gene-based [] synonym: "KIAA1437" RELATED Gene-based [] synonym: "UNQ221/PRO247" RELATED Gene-based [] synonym: "leucine-rich repeat-containing protein 8A" EXACT [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000057622 name: volume-regulated anion channel subunit LRRC8A O-glycosylated 1 (human) def: "A volume-regulated anion channel subunit LRRC8A (human) that has been O-glycosylated at the residue equivalent to Thr-89 of the amino acid sequence represented by UniProtKB:Q8IWT6-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8IWT6-1, Thr-89, MOD:00005~GNO:G43417UB." [GlyGen:Q8IWT6-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hLRRC8A/OGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8IWT6-1, Thr-89, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q8IWT6 ! volume-regulated anion channel subunit LRRC8A (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q8IWT6-1 name: volume-regulated anion channel subunit LRRC8A isoform 1 (human) def: "A volume-regulated anion channel subunit LRRC8A isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hLRRC8A/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8IWT6-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000041715 ! volume-regulated anion channel subunit LRRC8A isoform 1