[Term]
id: PR:000036119
name: activated IkappaB kinase complex (mouse)
def: "An activated IkappaB kinase complex whose components are encoded in the genome of mouse." [PMID:11080499, PRO:CNA]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated IKK complex (mouse)" RELATED []
is_a: PR:000035832 ! activated IkappaB kinase complex
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000036115 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse)
relationship: has_component PR:000036121 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
relationship: has_component PR:O88522 {cardinality="1"} ! NF-kappa-B essential modulator (mouse)

[Term]
id: PR:000035833
name: activated IkappaB kinase complex (human)
def: "An activated IkappaB kinase complex whose components are encoded in the genome of human." [Reactome:R-HSA-177663]
comment: Category=organism-complex.
synonym: "activated IKK complex (human)" RELATED []
xref: Reactome:R-HSA-177663 "PR:000035833 located_in GO:0005829"
is_a: PR:000035832 ! activated IkappaB kinase complex
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000026823 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
relationship: has_component PR:000035831 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human)
relationship: has_component PR:Q9Y6K9 {cardinality="1"} ! NF-kappa-B essential modulator (human)

[Term]
id: PR:000035832
name: activated IkappaB kinase complex
def: "An IKK complex where the IKKalpha and beta subunits are phosphorylated in the activation loop." [Reactome:R-HSA-177663]
comment: Category=complex. Requested by=TLR.
is_a: GO:0008385 ! IkappaB kinase complex