[Term]
id: PR:000036022
name: traf3:ticam1:ticam2:activated TLR4 complex (human)
def: "A traf3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PMID:16306936, PMID:16306937, Reactome:R-HSA-2201339]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TRAF3:TRIF:TRAM:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201339]
is_a: PR:000028681 ! traf3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000035702 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q13114 {cardinality="2"} ! TNF receptor-associated factor 3 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)