[Term]
id: PR:000036060
name: pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
def: "A pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:R-HSA-2562542]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 (human)" EXACT [Reactome:R-HSA-2562542]
is_a: PR:000036059 ! pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q13158 {cardinality="2"} ! FAS-associated death domain protein (human)
relationship: has_component PR:Q13546 {cardinality="2"} ! receptor-interacting serine/threonine-protein kinase 1 (human)
relationship: has_component PR:Q14790 {cardinality="2"} ! caspase-8 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000036059
name: pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), ticam2 (TRAM), ticam1 (TRIF), ripk1 (RIP1), fadd and the procaspase 8 precursor." [Reactome:R-HSA-2562542]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:RIP1:FADD:pro-caspase-8" RELATED [Reactome:R-HSA-2562542]
is_a: GO:0032991 ! protein-containing complex