[Term]
id: PR:000044684
name: activated TLR4 complex (human)
def: "An activated TLR4 complex whose components are encoded in the genome of human." [PMID:19252480, PRO:DAN]
comment: Category=organism-complex.
synonym: "hTLR4actv" EXACT PRO-short-label [PRO:DAN]
synonym: "MD2:LPS:TLR4 complex (human)" EXACT []
synonym: "LY96:LPS:TLR4 complex (human)" EXACT []
synonym: "TLR4MD2LPS complex dimer (human)" EXACT []
is_a: PR:000036076 ! activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)

[Term]
id: PR:000037474
name: activated TLR4 complex (chicken)
def: "An activated TLR4 complex whose components are encoded in the genome of chicken. LPS binding to Toll-like receptor 4 results in dimerization of the TLR4 associated with MD2." [PMID:18768894, PMID:24034933, Reactome:R-GGA-433789]
comment: Category=organism-complex. Requested by=TLR.
synonym: "chick-TLR4actv" EXACT PRO-short-label [PRO:DAN]
synonym: "chick-(LY96:LPS:TLR4)" EXACT [PRO:DAN]
synonym: "MD2:LPS:TLR4 (chicken)" EXACT []
synonym: "LY96:LPS:TLR4 complex (chicken)" EXACT []
xref: Reactome:R-GGA-433789 "PR:000037474 located_in GO:0005886"
is_a: PR:000036076 ! activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus
relationship: has_component PR:A0A1D5NZX9 {cardinality="2"} ! lymphocyte antigen 96 (chicken)
relationship: has_component PR:Q7ZTG5 {cardinality="2"} ! Toll-like receptor 4 (chicken)

[Term]
id: PR:000036076
name: activated TLR4 complex
def: "A protein-containing complex that contains TLR4, LPS and MD2(LY96)." [PMID:19252480, PRO:DAN, Reactome:R-HSA-166041, TLR:AMM]
comment: Category=complex. Requested by=TLR. Based on the crystal structure, known points of disulfide bonding, and other information, it is likely that the protein components correspond to PR:000003299 and PR:000025492. [PRO:DAN]
synonym: "TLR4actv" EXACT PRO-short-label [PRO:DAN]
synonym: "TLR4MD2LPS complex" EXACT []
synonym: "MD2:LPS:TLR4 complex" EXACT []
synonym: "LY96:LPS:TLR4 complex" EXACT []
is_a: GO:0043235 ! receptor complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component PR:000001155 {cardinality="2"} ! Toll-like receptor 4
relationship: has_component PR:000003296 {cardinality="2"} ! lymphocyte antigen 96

[Term]
id: PR:000036077
name: activated TLR4 complex (mouse)
def: "An activated TLR4 complex whose components are encoded in the genome of mouse." [PMID:23565187, PRO:DAN, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "mTLR4actv" EXACT PRO-short-label [PRO:DAN]
synonym: "MD2:LPS:TLR4 complex (mouse)" EXACT []
synonym: "LY96:LPS:TLR4 complex (mouse)" EXACT []
synonym: "TLR4MD2LPS complex dimer (mouse)" EXACT []
is_a: PR:000036076 ! activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)