[Term]
id: PR:000036078
name: TIRAP:PIP2:activated TLR4 complex
def: "A macromolecular complex that is composed of TIRAP (MAL) bound to phosphatidyl inositol 4,5-bisphosphate in complex with the TLR4:MD2:LPS complex." [PMID:12447442, TLR:AMM]
comment: Category=complex. Requested by=TLR.
synonym: "MAL:PIP2:MD2:LPS:TLR4" EXACT []
synonym: "Mal:activated TLR4 complex" EXACT []
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000027217
name: pTIRAP:PIP2:activated TLR4 complex (mouse)
def: "A TIRAP:PIP2:activated TLR4 complex that contains phosphorylated TIRAP/MAL in mouse." [TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "pMal:activated TLR4 complex (mouse)" EXACT []
is_a: PR:000036078 ! TIRAP:PIP2:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027216 ! Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse)

[Term]
id: PR:000036135
name: TIRAP:PIP2:activated TLR4 complex (human)
def: "A TIRAP:PIP2:activated TLR4 complex that contains phosphatidyl inositol bisphosphate bound to TIRAP/Mal in human." [Reactome:R-HSA-2559411]
comment: Category=organism-complex. Requested by=TLR.
synonym: "Mal:activated TLR4 complex (human)" EXACT [Reactome:R-HSA-2559411]
is_a: PR:000036078 ! TIRAP:PIP2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 (human)
relationship: has_component PR:P58753-1 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)

[Term]
id: PR:000027196
name: TIRAP:PIP2:activated TLR4 (mouse)
def: "A TIRAP:PIP2:activated TLR4 complex whose components are encoded in the genome of mouse." [PMID:11544529, PMID:12447442, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "TLR4MD2LPSditirap'" EXACT [TLR:AMM]
synonym: "Mal:activated TLR4 complex (mouse)" EXACT []
synonym: "TIRAP:PIP2:MD2:LPS:TLR4 complex (mouse)" EXACT [TLR:AMM]
is_a: PR:000036078 ! TIRAP:PIP2:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:Q99JY1 ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse)

[Term]
id: PR:000027218
name: pTIRAP:PIP2:activated TLR4 complex (human)
def: "A TIRAP:PIP2:activated TLR4 complex that contains phosphorylated TIRAP/MAL in human." [PMID:12724322, PMID:18070880, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
synonym: "pMal:activated TLR4 complex (human)" EXACT []
synonym: "pTIRAP:PIP2:MD2:LPS:TLR4 complex (human)" EXACT []
is_a: PR:000036078 ! TIRAP:PIP2:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027214 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)