[Term]
id: PR:000036122
name: p-tbk1/p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2, Ticam1, TRAF3 linked to Lys-63 polyubiquitin, and a phosphorylated kinase either tbk1 or IKKE." [Reactome:R-HSA-936970]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR4:TRAM:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKK epsilon" RELATED [Reactome:R-HSA-936970]
is_a: GO:0032991 ! protein-containing complex

[Term]
id: PR:000036123
name: p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
def: "A p-tbk1/p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex that contains the phosphorylated kinase tbk1 in human." [Reactome:R-HSA-936970]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRAM:TRIF:K63-poly-Ub-TRAF3:p-TBK1 (human)" RELATED [Reactome:R-HSA-936970]
is_a: PR:000036122 ! p-tbk1/p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028695 {cardinality="2"} ! serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000036124
name: p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
def: "A p-tbk1/p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex that contains the phosphorylated kinase IKKE in human." [Reactome:R-HSA-936970]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRAM:TRIF:K63-poly-Ub-TRAF3:p-IKK epsilon (human)" RELATED [Reactome:R-HSA-936970]
is_a: PR:000036122 ! p-tbk1/p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028691 {cardinality="2"} ! inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)