[Term]
id: PR:000036180
name: IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR3/TLR4 complex (human)
def: "A protein-containing complex that is composed of Ticam2 (TRAM), Ticam1 (TRIF), the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin, the IKK complex (consisting of IKKA, IKKB and NEMO), and either activated Toll-like receptor 4 (TLR4) or activated Toll-like receptor 3 (TLR3)." [PRO:DAN, Reactome:R-HSA-937030]
comment: Category=organism-complex.
synonym: "activated TLR3/TLR4:TRIF:K63-pUb-RIP1:IKKcomplex (human)" EXACT [Reactome:R-HSA-937030]
xref: Reactome:R-HSA-937030 "PR:000036180 located_in GO:00010008"
is_a: GO:0032991 ! protein-containing complex
union_of: PR:000036053 ! IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
union_of: PR:000037364 ! IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens