[Term]
id: PR:000036823
name: prM-E complex
def: "A protein-containing complex that involves the initial assembly of the dengue virion as an immature particle which contains prM noncovalently associated with E in a heterodimeric complex. It contains N-linked glycosylation sites at Asn-347, Asn-433, Asn-183. UniProtKB:P29990, 115-775, Asn-183/Asn-347/Asn-433, MOD:00160." [PMID:10590151, PRO:DAN, PRO:ES]
comment: Category=complex. Requested by=IDODEN. In the prME heterodimer, prM prevents an irreversible conformational change of E during virus secretion through acidified sorting compartments. Proteolysis of prM leads to the formation of homodimeric forms of E in virus particles before their release from the cell. [PMID:10590151, PRO:ES].
synonym: "prME" EXACT []
synonym: "DENV-prME" EXACT PRO-short-label [PRO:DAN]
is_a: GO:0032991 ! protein-containing complex
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: has_component PR:000036822 {cardinality="1"} ! E protein
relationship: has_component PR:000036837 {cardinality="1"} ! prM