[Term]
id: PR:000036839
name: NS345
def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [PMID:1433530, PRO:ES]
comment: Category=modification. Requested by=IDODEN. Cleavage at the NS2A-NS2B site was also mediated by the NS2B-NS3 protease, while the NS1-NS2A site was mediated by host cell-derived protease.
synonym: "DenV-NS345" EXACT PRO-short-label [PRO:DAN]
synonym: "NS3-NS4A-NS4B-NS5" EXACT []
intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product
intersection_of: lacks_part PR:000036824 ! NS1
intersection_of: lacks_part PR:000036825 ! NS2A
intersection_of: lacks_part PR:000036826 ! NS2A-alpha
intersection_of: lacks_part PR:000036827 ! NS2B
intersection_of: has_part PR:000036828 ! NS3
intersection_of: has_part PR:000036830 ! NS4A
intersection_of: has_part PR:000036831 ! 2K
intersection_of: has_part PR:000036833 ! NS4B
intersection_of: has_part PR:000036835 ! NS5
intersection_of: derives_from PR:000036838 ! NS12345