[Term]
id: PR:000037302
name: viral dsRNA:TLR3 complex
def: "A macromolecular complex that is composed of viral double stranded RNA (dsRNA) and a homodimer of TLR3. Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positively charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA." [PMID:18420935, PMID:20861016, PRO:CNA, PRO:DAN, Reactome:R-HSA-167985]
comment: Category=complex. Requested by=TLR.
synonym: "(vir)dsRNA:TLR3" EXACT PRO-short-label [PRO:DAN]
is_a: GO:0032991 ! protein-containing complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: has_component PR:000001154 {cardinality="2"} ! Toll-like receptor 3