[Term]
id: PR:000037303
name: viral dsRNA:TLR3 complex (human)
def: "A viral dsRNA:TLR3 complex whose components are encoded in the genome of human." [PMID:18172197, PMID:19595807, PRO:VS, Reactome:R-HSA-167985]
comment: Category=organism-complex. Requested by=TLR. Note: Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.
synonym: "h(vir)dsRNA:TLR3" EXACT PRO-short-label [PRO:DAN]
xref: Reactome:R-HSA-167985 "PR:000037303 located_in GO:0010008"
is_a: PR:000037302 ! viral dsRNA:TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)

[Term]
id: PR:000037302
name: viral dsRNA:TLR3 complex
def: "A macromolecular complex that is composed of viral double stranded RNA (dsRNA) and a homodimer of TLR3. Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positively charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA." [PMID:18420935, PMID:20861016, PRO:CNA, PRO:DAN, Reactome:R-HSA-167985]
comment: Category=complex. Requested by=TLR.
synonym: "(vir)dsRNA:TLR3" EXACT PRO-short-label [PRO:DAN]
is_a: GO:0032991 ! protein-containing complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: has_component PR:000001154 {cardinality="2"} ! Toll-like receptor 3

[Term]
id: PR:000037304
name: viral dsRNA:TLR3 complex (mouse)
def: "A viral dsRNA:TLR3 complex whose components are encoded in the genome of mouse." [PMID:18420935, PRO:CNA, TLR:AMM]
comment: Category=organism-complex. Requested by=TLR.
is_a: PR:000037302 ! viral dsRNA:TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000037789 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (mouse)

[Term]
id: PR:000037461
name: viral dsRNA:TLR3 complex (chicken)
def: "A viral dsRNA:TLR3 complex whose components are encoded in the genome of chicken." [PMID:17316136, PMID:18420935, PRO:VS, Reactome:R-GGA-433883]
comment: Category=organism-complex. Requested by=TLR. Note: Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.
xref: Reactome:R-GGA-433883 "PR:000037461 located_in GO:0010008"
is_a: PR:000037302 ! viral dsRNA:TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus
relationship: has_component PR:Q0PQ88 {cardinality="2"} ! Toll-like receptor 3 (chicken)