[Term]
id: PR:000037342
name: free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
def: "A free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PMID:12609980, PMID:16115877, PRO:VS, Reactome:R-HSA-936954]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-pUb-TRAF6:free K63-linked pUb:TAK1complex (human)" RELATED [Reactome:R-HSA-936954]
is_a: PR:000037341 ! free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000027103 {cardinality="2"} ! mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human)
relationship: has_component PR:000035714 {cardinality="2"} ! TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
relationship: has_component PR:000035732 {cardinality="2"} ! K63-polyubiquitin (human)
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)
relationship: has_component PR:O43318 {cardinality="2"} ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: has_component PR:Q15750 {cardinality="2"} ! TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)