[Term]
id: PR:000037356
name: IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
def: "An IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PMID:14517278, PMID:14739303, PMID:16281057, PRO:VS, Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKKE:IRF7 (human)" RELATED [Reactome:REACT_27000]
is_a: PR:000037355 ! IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000028695 {cardinality="2"} ! serine/threonine-protein kinase TBK1 phosphorylated 1 (human)
relationship: has_component PR:000028704 {cardinality="2"} ! interferon regulatory factor 7 unmodified form (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)
relationship: has_component PR:Q13114 {cardinality="2"} ! TNF receptor-associated factor 3 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000037355
name: IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated TBK1 and unphosphorylated IRF7." [PMID:14517278, PMID:14739303, PMID:16281057, Reactome:REACT_27000]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKKE:IRF7" RELATED [Reactome:REACT_27000]
is_a: GO:0032991 ! protein-containing complex