[Term]
id: PR:000037362
name: K63-pUb-rip1:ticam1:activated TLR3 complex (human)
def: "A K63-pUb-rip1:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PMID:15064760, PMID:15814722, PMID:16115877, PRO:VS, Reactome:R-HSA-937016]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-pUb-RIP1 (human)" RELATED [Reactome:R-HSA-937016]
is_a: PR:000037361 ! K63-pUb-rip1:ticam1:activated TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000036051 {cardinality="2"} ! receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)

[Term]
id: PR:000037361
name: K63-pUb-rip1:ticam1:activated TLR3 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), and the death receptor RIPK1 (RIP1) cross-linked to K63-linked polyubiquitin." [PMID:15064760, PMID:15814722, PMID:16115877, PRO:VS, Reactome:R-HSA-937016]
comment: Category=complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-pUb-RIP1" RELATED [Reactome:R-HSA-937016]
is_a: GO:0032991 ! protein-containing complex