[Term]
id: PR:000037364
name: IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
def: "An IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PMID:15064760, PMID:15814722, PMID:16115877, Reactome:R-HSA-937030]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-pUb-RIP1:IKKcomplex (human)" EXACT [Reactome:R-HSA-937030]
is_a: PR:000037363 ! IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000036051 {cardinality="2"} ! receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)
relationship: has_component PR:O14920 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit beta (human)
relationship: has_component PR:O15111 {cardinality="1"} ! inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)
relationship: has_component PR:Q9Y6K9 {cardinality="1"} ! NF-kappa-B essential modulator (human)