[Term]
id: PR:000037461
name: viral dsRNA:TLR3 complex (chicken)
def: "A viral dsRNA:TLR3 complex whose components are encoded in the genome of chicken." [PMID:17316136, PMID:18420935, PRO:VS, Reactome:R-GGA-433883]
comment: Category=organism-complex. Requested by=TLR. Note: Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.
xref: Reactome:R-GGA-433883 "PR:000037461 located_in GO:0010008"
is_a: PR:000037302 ! viral dsRNA:TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus
relationship: has_component PR:Q0PQ88 {cardinality="2"} ! Toll-like receptor 3 (chicken)