[Term] id: PR:000037477 name: TIRAP:PIP2:BTK:activated TLR4 complex (mouse) def: "A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine unphosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse." [TLR:AMM] comment: Category=organism-complex. Evidence=(ECO:0000088, based on PR:000037447). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial trasnfer of LPS. synonym: "MAL:PI(4,5)P2:BTK:activated TLR4 (mouse)" EXACT [] is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) relationship: has_component PR:P35991 {cardinality="2"} ! tyrosine-protein kinase BTK (mouse) relationship: has_component PR:Q99JY1 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse) [Term] id: PR:000037448 name: pTIRAP:PIP2:BTK:activated TLR4 complex (human) def: "A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS in human. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [PMID:12888566, Reactome:R-HSA-2201325] comment: Category=organism-complex. Kinase=("TIRAP:PIP2:BTK:activated TLR4 complex (human)"; PR:000037447). synonym: "p4Y-MAL:PIP2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201325] synonym: "p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201325] synonym: "p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201325] is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000027214 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human) relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 (human) relationship: has_component PR:000044351 {cardinality="2"} ! tyrosine-protein kinase BTK, initiator methionine removed form (human) [Term] id: PR:000037478 name: pTIRAP:PIP2:BTK:activated TLR4 complex (mouse) def: "A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [TLR:AMM] comment: Category=organism-complex. Evidence=(ECO:0000088, based on PR:000037448). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial transfer of LPS. synonym: "p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4" RELATED [] synonym: "p4Y-MAL:PIP2:BTK:activated TLR4 (mouse)" EXACT [] synonym: "p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (mouse)" EXACT [] is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) relationship: has_component PR:000027216 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse) relationship: has_component PR:P35991 {cardinality="2"} ! tyrosine-protein kinase BTK (mouse) [Term] id: PR:000037447 name: TIRAP:PIP2:BTK:activated TLR4 complex (human) def: "A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine unphosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS in human." [PMID:11544529, PMID:12724322, PMID:12888566, Reactome:R-HSA-2201331] comment: Category=organism-complex. synonym: "MAL:BTK:activated TLR4 (human)" RELATED [Reactome:R-HSA-2201331] synonym: "MAL:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201331] is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 (human) relationship: has_component PR:000044351 {cardinality="2"} ! tyrosine-protein kinase BTK, initiator methionine removed form (human) relationship: has_component PR:P58753 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein (human) [Term] id: PR:000037472 name: TIRAP:PIP2:BTK:activated TLR4 complex def: "A receptor complex that is composed of PI(4,5)P2, TIRAP/MAL, and BTK, bound to activated TLR4 complex." [PMID:11544529, PMID:12724322, PMID:12888566, Reactome:R-HSA-2201331] comment: Category=complex. synonym: "MAL:PI(4,5)P2:BTK:activated TLR4" EXACT [] is_a: GO:0043235 ! receptor complex