[Term]
id: PR:000037478
name: pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
def: "A TIRAP:PIP2:BTK:activated TLR4 complex that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [TLR:AMM]
comment: Category=organism-complex. Evidence=(ECO:0000088, based on PR:000037448). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial transfer of LPS.
synonym: "p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4" RELATED []
synonym: "p4Y-MAL:PIP2:BTK:activated TLR4 (mouse)" EXACT []
synonym: "p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (mouse)" EXACT []
is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027216 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse)
relationship: has_component PR:P35991 {cardinality="2"} ! tyrosine-protein kinase BTK (mouse)