[Term]
id: PR:000037446
name: MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
def: "A MYD88:TIRAP:PIP2:BTK:activated TLR4 complex that is composed of MyD88, PI(4,5)P2, TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS in human." [PMID:12888566, PMID:21873236, Reactome:R-HSA-166062]
comment: Category=organism-complex.
synonym: "MyD88:MAL:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-166062]
synonym: "MyD88:Mal complexed with the activated TLR (human)" RELATED [Reactome:R-HSA-166062]
is_a: PR:000037488 ! MYD88:TIRAP:PIP2:BTK:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027214 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule isoform 1 cleaved 2 (human)
relationship: has_component PR:000044351 {cardinality="2"} ! tyrosine-protein kinase BTK, initiator methionine removed form (human)
relationship: has_component PR:Q99836 {cardinality="2"} ! myeloid differentiation primary response protein MyD88 (human)

[Term]
id: PR:000037488
name: MYD88:TIRAP:PIP2:BTK:activated TLR4 complex
def: "A receptor complex that is composed of MYD88, PI(4,5)P2, TIRAP/MAL, BTK, and activated TLR4 receptor." [PMID:12888566, PMID:21873236, Reactome:R-HSA-166062]
comment: Category=complex.
synonym: "MyD88:MAL:PI(4,5)P2:BTK:activated TLR4" EXACT [Reactome:R-HSA-166062]
synonym: "MyD88:Mal complexed with the activated TLR" RELATED [Reactome:R-HSA-166062]
is_a: GO:0043235 ! receptor complex

[Term]
id: PR:000037481
name: MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
def: "A MYD88:TIRAP:PIP2:BTK:activated TLR4 complex that is composed of MyD88, PI(4,5)P2, TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse." [TLR:AMM]
comment: Category=organism-complex. Evidence=(ECO:0000088, based on PR:000037446). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial trasnfer of LPS. PMID:21441935 shows interaction of MYD88 with BTK.
synonym: "MyD88:MAL:PI(4,5)P2:BTK:activated TLR4 (mouse)" EXACT []
synonym: "MyD88:Mal complexed with the activated TLR (mouse)" RELATED []
is_a: PR:000037488 ! MYD88:TIRAP:PIP2:BTK:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:P22366-1 {cardinality="2"} ! myeloid differentiation primary response protein MyD88 isoform 1 (mouse)
relationship: has_component PR:P35991 {cardinality="2"} ! tyrosine-protein kinase BTK (mouse)
relationship: has_component PR:Q99JY1 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse)