[Term]
id: PR:000037512
name: G1/S-specific cyclin-D1 phosphorylated and multi-ubiquitinated 1 (human)
def: "A G1/S-specific cyclin-D1 (human) that has been both phosphorylated at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385 and been multi-ubiquitinated." [PMID:17081987, PMID:17407548, PRO:KER]
comment: Category=organism-modification. UbLigase=("FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex"; PR:000037513). Kinase=("GSK3B"; PR:P49841; Thr-286).
synonym: "hCCND1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "multi-ubiquitinated phospho-(T286) Cyclin D1 (human)" EXACT [Reactome:R-HSA-177997]
xref: Reactome:R-HSA-177997 "PR:000037512 located_in GO:0005829"
is_a: PR:P24385 ! G1/S-specific cyclin-D1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens