[Term]
id: PR:000047321
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphorylated 5 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 877, 1023, 1112, 1139, 1196, 1221, 1222 and 1248 of the amino acid sequence represented by UniProtKB:P04626. UniProtKB:P04626, 23-1255, Tyr-877/Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864079]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, Tyr-877/Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, Tyr-877/Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8864079 "PR:000047321 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide