[Term]
id: PR:000050166
name: dimeric IgA1 immunoglobulin complex (human)
def: "A polymeric IgA1 immunoglobulin complex (human) that is composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Dimeric IgA1 is by far the most common form of polymeric IgA1. In human only the IgA1 isotype is capable of a dimeric form.
synonym: "h(IgA1)dimeric" EXACT PRO-short-label [PRO:DAN]
synonym: "dimeric IgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "dimeric IgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: PR:000050165 ! polymeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:P01591 ! immunoglobulin J chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050167
name: secretory polymeric IgA1 immunoglobulin complex (human)
def: "A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.
synonym: "sIgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "sIgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
synonym: "h(IgA1/secretory)polymeric" EXACT PRO-short-label [PRO:DAN]
synonym: "secretory IgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "secretory IgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: PR:000050165 ! polymeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050169 ! polymeric immunoglobulin receptor secretory component (human)
intersection_of: has_component PR:P01591 ! immunoglobulin J chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050165
name: polymeric IgA1 immunoglobulin complex (human)
def: "An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Dimeric IgA1 is by far the most common form of polymeric IgA1. In human only the IgA1 isotype is capable of a polymeric forms.
synonym: "h(IgA1)polymeric" EXACT PRO-short-label [PRO:DAN]
synonym: "pIgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "pIgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
synonym: "polymeric IgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "polymeric IgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
intersection_of: PR:000050159 ! IgA1 immunoglobulin complex, circulating (human)
intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:P01591 ! immunoglobulin J chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050168
name: secretory dimeric IgA1 immunoglobulin complex (human)
def: "A dimeric form of secretory IgA1 immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Note that an IgA1 immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA1 is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.
synonym: "h(IgA1/secretory)dimeric" EXACT PRO-short-label [PRO:DAN]
synonym: "secretory dimeric IgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "secretory dimeric IgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: PR:000050165 ! polymeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050169 ! polymeric immunoglobulin receptor secretory component (human)
intersection_of: has_component PR:P01591 ! immunoglobulin J chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens