[Term] id: PR:000050167 name: secretory polymeric IgA1 immunoglobulin complex (human) def: "A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD] comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA. synonym: "sIgA antibody (human)" BROAD [PRO:ADD, GOC:add] synonym: "sIgA1 antibody (human)" EXACT [PRO:ADD, GOC:add] synonym: "h(IgA1/secretory)polymeric" EXACT PRO-short-label [PRO:DAN] synonym: "secretory IgA antibody (human)" BROAD [PRO:ADD, GOC:add] synonym: "secretory IgA1 antibody (human)" EXACT [PRO:ADD, GOC:add] intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human) intersection_of: has_component PR:000050163 ! monomeric IgA1 immunoglobulin complex (human) intersection_of: PR:000050165 ! polymeric IgA1 immunoglobulin complex (human) intersection_of: has_component PR:000050169 ! polymeric immunoglobulin receptor secretory component (human) intersection_of: has_component PR:P01591 ! immunoglobulin J chain (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens