PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000000759 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human) hHCN4/var:D553N|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human)|UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347 NOT located_in GO:0005886 plasma membrane PMID:15123648 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_026534 20080601 PRO:CNA PR:000000759 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human) hHCN4/var:D553N|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human)|UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347 associated_with_disease_progression DOID:13884 sick sinus syndrome PMID:15123648 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_026534 20080601 PRO:CNA PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human) hHCN4/var:S672R|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)|UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 enables GO:0005222 intracellular cAMP-activated cation channel activity PMID:16407510 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_026535 20080601 PRO:CNA PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human) hHCN4/var:S672R|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)|UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 altered enables GO:0022843 voltage-gated cation channel activity PR:000002604 PMID:16407510 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_026535 20080601 PRO:CNA PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human) hHCN4/var:S672R|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)|UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 associated_with_disease_progression DOID:13884 sick sinus syndrome PMID:16407510 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_026535 20080601 PRO:CNA PR:Q9TV66-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform r1 (rabbit) rabbit-HCN4/iso:r1 located_in GO:0005886 plasma membrane PMID:15123648 IDA NCBITaxon:9986 UniProtKB:Q9TV66-1 20080601 PRO:CNA PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human) hHCN4/iso:1 acts_upstream_of_or_within GO:0006812 cation transport PMID:10228147 IDA NCBITaxon:9606 UniProtKB:Q9Y3Q4-1 20080601 PRO:CNA PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human) hHCN4/iso:1 acts_upstream_of_or_within GO:0006936 muscle contraction PMID:10228147 IDA NCBITaxon:9606 UniProtKB:Q9Y3Q4-1 20080601 PRO:CNA PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human) hHCN4/iso:1 enables GO:0005261 cation channel activity PMID:10228147 IDA NCBITaxon:9606 UniProtKB:Q9Y3Q4-1 20080601 PRO:CNA