PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0007059 chromosome segregation PMID:16580887 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O08901 mitotic checkpoint serine/threonine-protein kinase BUB1 (mouse) Bub1|BUB1A (mouse)|mBUB1 located_in GO:0000775 chromosome, centromeric region PMID:19965387 EXP NCBITaxon:10090 MGI:5426470|PMID:22573681 UniProtKB:O08901 20130102 PRO:KER Timing=prometaphase and metaphase of Meiosis I PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0007062 sister chromatid cohesion PMID:16580887 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human) hBUB1 phosphorylated|hBUB1/Phos:10|UniProtKB:O43683-1, Ser-314, MOD:00046 acts_upstream_of_or_within GO:0006281 DNA repair PMID:22071147 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human) hBUB1 phosphorylated|hBUB1/Phos:10|UniProtKB:O43683-1, Ser-314, MOD:00046 located_in GO:0035861 site of double-strand break PMID:22071147 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 located_in GO:0000940 outer kinetochore PMID:11792804|PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:000035419 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast) BUB1p phosphorylated|UniProtKB:P41695, Thr-566, MOD:00047|yBUB1/Phos:CDK-1 NOT acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:21298086 EXP NCBITaxon:559292 UniProtKB:P41695 20121105 PRO:KER PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human) hBUB1 phosphorylated|hBUB1/Phos:10|UniProtKB:O43683-1, Ser-314, MOD:00046 acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:22099307 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog) frog-BUB1/Phos:3|UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046|xBUB1 hyperphosphorylated acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15241477 EXP NCBITaxon:8355 UniProtKB:Q6GPC9-1 20121105 PRO:KER PR:O08901 mitotic checkpoint serine/threonine-protein kinase BUB1 (mouse) Bub1|BUB1A (mouse)|mBUB1 acts_upstream_of_or_within GO:0043069 negative regulation of programmed cell death PMID:20057499 EXP NCBITaxon:10090 MGI:1350695|PMID:10601341 UniProtKB:O08901 20130102 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0043069 negative regulation of programmed cell death PMID:20057499 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:19252416 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:000029911 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog) frog-BUB1/Phos:1|xBUB1 phosphorylated increased enables GO:0016301 kinase activity PR:000029917 PMID:11231148 EXP NCBITaxon:8355 UniProtKB:Q98UH3 20120912 PRO:KER Timing=Meiosis I (prophase I, metaphase I, anaphase I, telophase I), Meiosis II (prophase II, metaphase II). PR:000035410 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-) Spom972h-BUB1/Phos:5 acts_upstream_of_or_within GO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573 EXP NCBITaxon:284812 UniProtKB:O94751 20121105 PRO:KER PR:000035411 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-) Spom972h-BUB1/Phos:6|UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046) acts_upstream_of_or_within GO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573 EXP NCBITaxon:284812 UniProtKB:O94751 20121105 PRO:KER PR:Q98UH3 mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog) frog-BUB1/var:1 acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:12163471 EXP NCBITaxon:8355 UniProtKB:Q98UH3 20130102 PRO:KER Target=PR:Q8JGT8. PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog) frog-BUB1/Phos:3|UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046|xBUB1 hyperphosphorylated acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477 EXP NCBITaxon:8355 UniProtKB:Q6GPC9-1 20121105 PRO:KER Target=PR:Q6GPD1. PR:000035412 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human) hBUB1/Phos:7|UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047 acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:Q9NQS7. PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog) frog-BUB1/Phos:3|UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046|xBUB1 hyperphosphorylated acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477 EXP NCBITaxon:8355 UniProtKB:Q6GPC9-1 20121105 PRO:KER Target=PR:P79935. PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog) frog-BUB1/Phos:3|UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046|xBUB1 hyperphosphorylated acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477 EXP NCBITaxon:8355 UniProtKB:Q6GPC9-1 20121105 PRO:KER Target=PR:Q9YGY3-2. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 located_in GO:0000939 inner kinetochore PMID:11792804 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:Q5FBB7. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=phospho-Thr-3-Histone H3. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:Q96GD4. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16580887 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:P30153. PR:000035411 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-) Spom972h-BUB1/Phos:6|UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046) located_in GO:0000776 kinetochore PMID:12606573 EXP NCBITaxon:284812 UniProtKB:O94751 20121105 PRO:KER Timing=spindle disruption. PR:000035405 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human) hBUB1/PhosRes- located_in GO:0000776 kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O43683 20130102 PRO:KER Timing=spindle disruption (nocodazole). PR:Q98UH3 mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog) frog-BUB1/var:1 located_in GO:0000776 kinetochore PMID:11231148|PMID:12163471 EXP NCBITaxon:8355 UniProtKB:Q98UH3 20120912 PRO:KER Timing=Meiosis I, Meiosis II, Mitosis (prophase, metaphase, anaphase). PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 located_in GO:0000776 kinetochore PMID:20624902 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Timing=Mitosis (prophase, prometaphase, metaphase) and spindle disruption (nocodazole). Localization is increased by PR:Q9NQS7. PR:Q98UH3 mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog) frog-BUB1/var:1 enables GO:0005515 protein binding PR:Q9YGY3 PMID:11231148 IPI NCBITaxon:8355 UniProtKB:Q98UH3 20120912 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:P53350 BioGRID:BG-718371 IPI NCBITaxon:9606 UniProtKB:O43683 20130103 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:Q9Y6D9 PMID:10198256 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:P04637-1 PMID:19252416 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:P25054 BioGRID:BG-302960 IPI NCBITaxon:9606 UniProtKB:O43683 20130103 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:O60566 PMID:11792804 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Note=Interaction observed in nocodazole. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:O43684 PMID:10198256|PMID:15525512 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Note=Interaction observed through out the cell cycle. PR:000035405 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human) hBUB1/PhosRes- NOT enables GO:0005515 protein binding PR:P53350 PMID:16760428 IPI NCBITaxon:9606 UniProtKB:O43683 20130102 PRO:KER Timing=spindle disruption (nocodazole). PR:000035412 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human) hBUB1/Phos:7|UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047 increased enables GO:0005515 protein binding PR:000035414 PR:Q9NQS7 PMID:16760428 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Timing=Mitosis and spindle disruption (nocodazole). PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:Q8NG31 BioGRID:BG-723200 IPI NCBITaxon:9606 UniProtKB:O43683 20130103 PRO:KER PR:Q98UH3 mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog) frog-BUB1/var:1 located_in GO:0005694 chromosome PMID:15241477|PMID:16950116 EXP NCBITaxon:8355 UniProtKB:Q98UH3 20130102 PRO:KER PR:000035410 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-) Spom972h-BUB1/Phos:5 acts_upstream_of_or_within GO:0045143 homologous chromosome segregation PMID:12606573 EXP NCBITaxon:284812 UniProtKB:O94751 20121105 PRO:KER PR:000035411 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-) Spom972h-BUB1/Phos:6|UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046) acts_upstream_of_or_within GO:0045143 homologous chromosome segregation PMID:12606573 EXP NCBITaxon:284812 UniProtKB:O94751 20121105 PRO:KER PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human) hBUB1 phosphorylated|hBUB1/Phos:10|UniProtKB:O43683-1, Ser-314, MOD:00046 increased enables GO:0004672 protein kinase activity PR:000035405 PMID:22071147 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:000044898. PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog) frog-BUB1/Phos:3|UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046|xBUB1 hyperphosphorylated increased enables GO:0004672 protein kinase activity PR:000029917 PMID:15241477 EXP NCBITaxon:8355 UniProtKB:Q6GPC9-1 20121105 PRO:KER PR:000035407 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human) hBUB1 phosphorylated|hBUB1/Phos:4 increased enables GO:0004672 protein kinase activity PR:000035405 PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0004672 protein kinase activity PMID:10198256 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER