PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000027724 estrogen receptor isoform 1 phosphorylated 1 (human) hESR1/iso:1/Phos:1|phospho-ERalpha-Ser-167|UniProtKB:P03372-1, Ser-167, MOD:00046 acts_upstream_of_or_within GO:0045893 positive regulation of DNA-templated transcription PMID:19940156 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110901 PRO:PD Kinase=IKKepsilon [PR:Q14164; PR:000001778] PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human) hESR1/iso:1/Phos:2|UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048 located_in GO:0005634 nucleus PMID:20101225 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110901 PRO:CNA Kinase=c-Abl tyrosine kinase [PR:P00519; PR:000003582]. interaction mediated by two PXXP motifs of ERalpha and the c-Abl SH3 domain PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human) hESR1/iso:1/Phos:2|UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048 enables GO:0042803 protein homodimerization activity PMID:20101225 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110901 PRO:CNA Kinase=c-Abl tyrosine kinase [PR:P00519; PR:000003582]. interaction mediated by two PXXP motifs of ERalpha and the c-Abl SH3 domain PR:000027726 estrogen receptor isoform 1 phosphorylated 2 (human) hESR1/iso:1/Phos:2|UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048 acts_upstream_of_or_within GO:0010628 positive regulation of gene expression PMID:20101225 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110901 PRO:PD Kinase=c-Abl tyrosine kinase [PR:P00519; PR:000003582]. interaction mediated by two PXXP motifs of ERalpha and the c-Abl SH3 domain PR:000027756 estrogen receptor isoform 1 acetylated 1 (human) AcK266/268-ERalpha (human)|ERalpha acetylated (human)|hESR1/iso:1/Ac:1|UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064 enables GO:0003677 DNA binding PMID:16497729 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110909 PRO:PD Acetylase=EP300 [PR:Q09472; PR:000007102] PR:000027776 estrogen receptor isoform 1 phosphorylated 4 (human) hESR1/iso:1/Phos:4|pERalpha-Thr311|UniProtKB:P03372-1, Thr-311, MOD:00047 located_in GO:0005634 nucleus PMID:12138194 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110920 PRO:PD Kinase=p38 MAPK [PR:Q16539; PR:000003107]. PR:000027776 estrogen receptor isoform 1 phosphorylated 4 (human) hESR1/iso:1/Phos:4|pERalpha-Thr311|UniProtKB:P03372-1, Thr-311, MOD:00047 acts_upstream_of_or_within GO:0010628 positive regulation of gene expression PMID:12138194 EXP NCBITaxon:9606 UniProtKB:P03372-1 20110920 PRO:PD Kinase=p38 MAPK [PR:Q16539; PR:000003107].