PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000044818 serine/threonine-protein kinase PLK1 phosphorylated 1 (human) hPLK1/Phos:1|UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047 enables GO:0071889 14-3-3 protein binding PR:P61981 PMID:23695676 IPI NCBITaxon:9606 UniProtKB:P53350-1 20150504 PRO:CNA PR:000044818 serine/threonine-protein kinase PLK1 phosphorylated 1 (human) hPLK1/Phos:1|UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047 acts_upstream_of_or_within GO:0007091 metaphase/anaphase transition of mitotic cell cycle PMID:23695676 EXP NCBITaxon:9606 UniProtKB:P53350-1 20150504 PRO:CNA PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) acts_upstream_of_or_within GO:0051310 metaphase plate congression PMID:17376779 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) located_in GO:0000940 outer kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) NOT acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) acts_upstream_of_or_within GO:0034092 negative regulation of maintenance of sister chromatid cohesion PMID:16580887 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) NOT acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER Target=PR:O43683. PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) NOT acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER Target=PR:O60566. PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER Target=PR:Q13257. PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) acts_upstream_of_or_within GO:0008608 attachment of spindle microtubules to kinetochore PMID:17376779 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) located_in GO:0000922 spindle pole PMID:20823832 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) located_in GO:0005813 centrosome PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) located_in GO:0000776 kinetochore PMID:20624902 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER Timing=Mitosis and spindle disruption (nocodazole). Localization increased by PR:000035412 and PR:Q9NQS7. PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) enables GO:0005515 protein binding PR:O14641 PMID:20823832 IPI NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER Timing=Mitosis. PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) enables GO:0005515 protein binding PR:O43683 BioGRID:BG-718371 IPI NCBITaxon:9606 UniProtKB:P53350 20130103 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) enables GO:0005515 protein binding PR:O60566 PMID:17376779 IPI NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) enables GO:0005515 protein binding PR:Q5FBB7 BioGRID:BG-338598 IPI NCBITaxon:9606 UniProtKB:P53350 20130103 PRO:KER PR:P53350 serine/threonine-protein kinase PLK1 (human) hPLK1|PLK|PLK-1 (human)|PLK1|Polo-like kinase 1 (human)|serine/threonine-protein kinase 13 (human)|STPK13 (human) enables GO:0004672 protein kinase activity PMID:16760428 EXP NCBITaxon:9606 UniProtKB:P53350 20121105 PRO:KER