PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000000367 smad4 sequence variant E330G (human) hSMAD4/var:E330G|smad4 sequence variant 1 (human)|UniProtKB:Q13485, Glu-330, CHEBI:29947 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_022833 20080301 PRO:CNA PR:000000368 smad4 sequence variant G352R (human) hSMAD4/var:G352R|smad4 sequence variant 2 (human)|UniProtKB:Q13485, Gly-352, CHEBI:29952 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_019571 20080301 PRO:CNA PR:000000368 smad4 sequence variant G352R (human) hSMAD4/var:G352R|smad4 sequence variant 2 (human)|UniProtKB:Q13485, Gly-352, CHEBI:29952 associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:12417513 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_019571 20080301 PRO:CNA PR:000000369 smad4 sequence variant R361C (human) hSMAD4/var:R361C|smad4 sequence variant 3 (human)|UniProtKB:Q13485, Arg-361, CHEBI:29950 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:9811934 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_019572 20080301 PRO:CNA PR:000000370 smad4 sequence variant G386D (human) hSMAD4/var:G386D|smad4 sequence variant 4 (human)|UniProtKB:Q13485, Gly-386, CHEBI:29958 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:15031030 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_019573 20080301 PRO:CNA PR:000000371 smad4 sequence variant D493H (human) hSMAD4/var:D493H|smad4 sequence variant 5 (human)|UniProtKB:Q13485, Asp-493, CHEBI:29979 associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:8553070 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011380 20080301 PRO:CNA PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human) hSMAD4/iso:1/MonoUbiq:2|UniProtKB:Q13485-1, Lys-519, MOD:01148 acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894 EXP NCBITaxon:9606 UniProtKB:Q13485-1 20101005 PRO:CNA PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human) hSMAD4/iso:1/MonoUbiq:2|UniProtKB:Q13485-1, Lys-519, MOD:01148 NOT enables GO:0046332 SMAD binding PMID:19135894 EXP NCBITaxon:9606 UniProtKB:Q13485-1 20101005 PRO:CNA PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human) hSMAD4/iso:1/Phos:1|UniProtKB:Q13485-1, Thr-277, MOD:00047 located_in GO:0005634 nucleus PMID:12801888 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human) hSMAD4/iso:1/Phos:1|UniProtKB:Q13485-1, Thr-277, MOD:00047 increased enables GO:0003700 DNA-binding transcription factor activity PR:000002539 PMID:12801888 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human) hSMAD4/iso:1/Phos:1|UniProtKB:Q13485-1, Thr-277, MOD:00047 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 located_in GO:0005634 nucleus PMID:10980615|PMID:15280432 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 part_of GO:0005667 transcription factor complex PMID:12374795 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 enables GO:0003700 DNA-binding transcription factor activity PMID:10823886 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:14633973 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 located_in GO:0005737 cytoplasm PMID:15280432 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 enables GO:0003712 transcription coregulator activity PMID:10980615 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:10980615|PMID:15350224|PMID:9346966 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805|PMID:8774881 IDA NCBITaxon:9606 UniProtKB:Q13485-1 20080301 PRO:CNA