PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000026335 TGF-beta 1 isoform 1 inactive form (human) hTGFB1/iso:1/inactive|PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160|UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 part_of GO:0032991 protein-containing complex PMID:3162913 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human) hTGFB1/iso:1/LAP|UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160 part_of GO:0032991 protein-containing complex PMID:17015622|PMID:3162913 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000403 TGF-beta 1 sequence variant C225R (human) hTGFB1/var:C225R|TGF-beta 1 sequence variant 6 (human)|UniProtKB:P01137, Cys-225, CHEBI:29952 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000000399 TGF-beta 1 sequence variant T81H (human) hTGFB1/var:T81H|TGF-beta 1 sequence variant 2 (human)|UniProtKB:P01137, Tyr-81, CHEBI:29979 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000400 TGF-beta 1 sequence variant R218C (human) hTGFB1/var:R218C|TGF-beta 1 sequence variant 3 (human)|UniProtKB:P01137, Arg-218, CHEBI:29950 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:10973241|PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000401 TGF-beta 1 sequence variant R218H (human) hTGFB1/var:R218H|TGF-beta 1 sequence variant 4 (human)|UniProtKB:P01137, Arg-218, CHEBI:29979 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000402 TGF-beta 1 sequence variant H222D (human) hTGFB1/var:H222D|TGF-beta 1 sequence variant 5 (human)|UniProtKB:P01137, His-222, CHEBI:29958 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human) hTGFB1/var:R218C/Clv:1|TGF-beta 1 sequence variant 3 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 enables GO:0042803 protein homodimerization activity PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000026335 TGF-beta 1 isoform 1 inactive form (human) hTGFB1/iso:1/inactive|PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160|UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 enables GO:0042803 protein homodimerization activity PMID:3162913 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human) hTGFB1/var:R218H/Clv:1|TGF-beta 1 sequence variant 4 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 enables GO:0042803 protein homodimerization activity PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:P01137-1 transforming growth factor beta-1 isoform 1 (human) hTGFB1/iso:1 enables GO:0042803 protein homodimerization activity PMID:1544940 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000025927 TGF-beta 1 isoform 1 mature form (human) hTGFB1/iso:1/mature|PRO_0000033763|UniProtKB:P01137-1, 279-390 enables GO:0042803 protein homodimerization activity PMID:3162913|PMID:8471846 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000026335 TGF-beta 1 isoform 1 inactive form (human) hTGFB1/iso:1/inactive|PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160|UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 NOT enables GO:0005160 transforming growth factor beta receptor binding PMID:2677679|PMID:3162913 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human) hTGFB1/var:R218H/Clv:1|TGF-beta 1 sequence variant 4 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 enables GO:0005160 transforming growth factor beta receptor binding PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human) hTGFB1/var:R218C/Clv:1|TGF-beta 1 sequence variant 3 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 enables GO:0005160 transforming growth factor beta receptor binding PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000400 TGF-beta 1 sequence variant R218C (human) hTGFB1/var:R218C|TGF-beta 1 sequence variant 3 (human)|UniProtKB:P01137, Arg-218, CHEBI:29950 increased enables GO:0008083 growth factor activity PR:000002555 PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000403 TGF-beta 1 sequence variant C225R (human) hTGFB1/var:C225R|TGF-beta 1 sequence variant 6 (human)|UniProtKB:P01137, Cys-225, CHEBI:29952 increased enables GO:0008083 growth factor activity PR:000002555 PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human) hTGFB1/var:C225R/Clv:1|TGF-beta 1 sequence variant 6 cleaved 1 (human)|UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 increased enables GO:0008083 growth factor activity PR:000000616 PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human) hTGFB1/var:H222D/Clv:1|TGF-beta 1 sequence variant 5 cleaved 1 (human)|UniProtKB:P01137, 279-390, His-222, CHEBI:29958 increased enables GO:0008083 growth factor activity PR:000000616 PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human) hTGFB1/var:R218H/Clv:1|TGF-beta 1 sequence variant 4 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 increased enables GO:0008083 growth factor activity PR:000000616 PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human) hTGFB1/var:R218C/Clv:1|TGF-beta 1 sequence variant 3 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 increased enables GO:0008083 growth factor activity PR:000000616 PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human) hTGFB1/var:H222D/Clv:2|TGF-beta 1 sequence variant 5 cleaved 2 (human)|UniProtKB:P01137, 30-278, His-222, CHEBI:29958 has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human) hTGFB1/var:R218H/Clv:2|TGF-beta 1 sequence variant 4 cleaved 2 (human)|UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human) hTGFB1/var:C225R/Clv:2|TGF-beta 1 sequence variant 6 cleaved 2 (human)|UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human) hTGFB1/var:R218C/Clv:2|TGF-beta 1 sequence variant 3 cleaved 2 (human)|UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human) hTGFB1/var:H222D/Clv:2|TGF-beta 1 sequence variant 5 cleaved 2 (human)|UniProtKB:P01137, 30-278, His-222, CHEBI:29958 has_agent SO:0001601 conformational_change_variant PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human) hTGFB1/var:R218H/Clv:2|TGF-beta 1 sequence variant 4 cleaved 2 (human)|UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 has_agent SO:0001601 conformational_change_variant PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000399 TGF-beta 1 sequence variant T81H (human) hTGFB1/var:T81H|TGF-beta 1 sequence variant 2 (human)|UniProtKB:P01137, Tyr-81, CHEBI:29979 has_agent SO:0001558 polypeptide_localization_variant PMID:11062463|PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human) hTGFB1/var:T81H/Clv:1|TGF-beta 1 sequence variant 2 cleaved 1 (human)|UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 has_agent SO:0001558 polypeptide_localization_variant PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000403 TGF-beta 1 sequence variant C225R (human) hTGFB1/var:C225R|TGF-beta 1 sequence variant 6 (human)|UniProtKB:P01137, Cys-225, CHEBI:29952 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000025927 TGF-beta 1 isoform 1 mature form (human) hTGFB1/iso:1/mature|PRO_0000033763|UniProtKB:P01137-1, 279-390 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:9918798 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:P01137-1 transforming growth factor beta-1 isoform 1 (human) hTGFB1/iso:1 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:9918798 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000400 TGF-beta 1 sequence variant R218C (human) hTGFB1/var:R218C|TGF-beta 1 sequence variant 3 (human)|UniProtKB:P01137, Arg-218, CHEBI:29950 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human) hTGFB1/var:H222D/Clv:1|TGF-beta 1 sequence variant 5 cleaved 1 (human)|UniProtKB:P01137, 279-390, His-222, CHEBI:29958 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000402 TGF-beta 1 sequence variant H222D (human) hTGFB1/var:H222D|TGF-beta 1 sequence variant 5 (human)|UniProtKB:P01137, His-222, CHEBI:29958 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000182 TGF-beta 1 TGF-beta-1|TGFB|TGFB1 acts_upstream_of_or_within GO:0008283 cell population proliferation PANTHER:PTHR11848:SF32 ISS PANTHER:PTHR11848:SF32 PANTHER:PTHR11848:SF32 20080301 PRO:CNA PR:000000182 TGF-beta 1 TGF-beta-1|TGFB|TGFB1 acts_upstream_of_or_within GO:0030154 cell differentiation PANTHER:PTHR11848:SF32 ISS PANTHER:PTHR11848:SF32 PANTHER:PTHR11848:SF32 20080301 PRO:CNA PR:000026335 TGF-beta 1 isoform 1 inactive form (human) hTGFB1/iso:1/inactive|PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160|UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 located_in GO:0031012 extracellular matrix PMID:17015622|PMID:8294500 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000025927 TGF-beta 1 isoform 1 mature form (human) hTGFB1/iso:1/mature|PRO_0000033763|UniProtKB:P01137-1, 279-390 located_in GO:0031012 extracellular matrix PMID:8294500 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000399 TGF-beta 1 sequence variant T81H (human) hTGFB1/var:T81H|TGF-beta 1 sequence variant 2 (human)|UniProtKB:P01137, Tyr-81, CHEBI:29979 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000400 TGF-beta 1 sequence variant R218C (human) hTGFB1/var:R218C|TGF-beta 1 sequence variant 3 (human)|UniProtKB:P01137, Arg-218, CHEBI:29950 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000398 TGF-beta 1 sequence variant L10P (human) hTGFB1/var:L10P|TGF-beta 1 sequence variant 1 (human)|UniProtKB:P01137, Leu-10, CHEBI:50342 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9783545 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_016171 20080301 PRO:CNA PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human) hTGFB1/var:R218H/Clv:1|TGF-beta 1 sequence variant 4 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human) hTGFB1/var:R218C/Clv:1|TGF-beta 1 sequence variant 3 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000402 TGF-beta 1 sequence variant H222D (human) hTGFB1/var:H222D|TGF-beta 1 sequence variant 5 (human)|UniProtKB:P01137, His-222, CHEBI:29958 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000026335 TGF-beta 1 isoform 1 inactive form (human) hTGFB1/iso:1/inactive|PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160|UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human) hTGFB1/var:H222D/Clv:1|TGF-beta 1 sequence variant 5 cleaved 1 (human)|UniProtKB:P01137, 279-390, His-222, CHEBI:29958 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000403 TGF-beta 1 sequence variant C225R (human) hTGFB1/var:C225R|TGF-beta 1 sequence variant 6 (human)|UniProtKB:P01137, Cys-225, CHEBI:29952 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000025927 TGF-beta 1 isoform 1 mature form (human) hTGFB1/iso:1/mature|PRO_0000033763|UniProtKB:P01137-1, 279-390 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:P01137-1 transforming growth factor beta-1 isoform 1 (human) hTGFB1/iso:1 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:1544940 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:P01137-1 transforming growth factor beta-1 isoform 1 (human) hTGFB1/iso:1 located_in GO:0005796 Golgi lumen PMID:1544940 IDA NCBITaxon:9606 UniProtKB:P01137-1 20080301 PRO:CNA PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human) hTGFB1/var:R218H/Clv:1|TGF-beta 1 sequence variant 4 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 located_in GO:0005615 extracellular space PMID:11278244 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000403 TGF-beta 1 sequence variant C225R (human) hTGFB1/var:C225R|TGF-beta 1 sequence variant 6 (human)|UniProtKB:P01137, Cys-225, CHEBI:29952 located_in GO:0005615 extracellular space PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human) hTGFB1/var:R218C/Clv:1|TGF-beta 1 sequence variant 3 cleaved 1 (human)|UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 located_in GO:0005615 extracellular space PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017608 20080301 PRO:CNA PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human) hTGFB1/var:H222D/Clv:1|TGF-beta 1 sequence variant 5 cleaved 1 (human)|UniProtKB:P01137, 279-390, His-222, CHEBI:29958 located_in GO:0005615 extracellular space PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017610 20080301 PRO:CNA PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human) hTGFB1/var:T81H/Clv:2|TGF-beta 1 sequence variant 2 cleaved 2 (human)|UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 located_in GO:0005615 extracellular space PMID:12493741 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017607 20080301 PRO:CNA PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human) hTGFB1/var:C225R/Clv:1|TGF-beta 1 sequence variant 6 cleaved 1 (human)|UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 located_in GO:0005615 extracellular space PMID:11062463|PMID:12493741|PMID:12843182 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_017611 20080301 PRO:CNA