PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000025942 smad2 isoform Long phosphorylated 1 (mouse) mSMAD2/iso:Long/Phos:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046 located_in GO:0005634 nucleus PMID:11557747 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human) hSMAD2/iso:Long/AcPhos:1|UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046 located_in GO:0005634 nucleus PMID:17074756 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 located_in GO:0005634 nucleus PMID:9006934|PMID:9346966 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 located_in GO:0005634 nucleus PMID:12193595|PMID:17074053 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000000471 smad2 sequence variant L440R (human) hSMAD2/var:L440R|smad2 sequence variant 2 (human)|UniProtKB:Q15796-1, Leu-440, CHEBI:29952 associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011377 20080301 PRO:CNA PR:000000473 smad2 sequence variant D450E (human) hSMAD2/var:D450E|smad2 sequence variant 4 (human)|UniProtKB:Q15796-1, Asp-450, CHEBI:29972 associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011379 20080301 PRO:CNA PR:000000474 smad2 sequence variant 5 (human) hSMAD2/var:5|UniProtKB:Q15796-1, 2-343, 359-467 associated_with_disease_progression DOID:5672 large intestine cancer PMID:8673135 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011376 20080301 PRO:CNA PR:000000470 smad2 sequence variant R133C (human) hSMAD2/var:R133C|smad2 sequence variant 1 (human)|UniProtKB:Q15796-1, Arg-133, CHEBI:29950 associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011375 20080301 PRO:CNA PR:000000472 smad2 sequence variant P445H (human) hSMAD2/var:P445H|smad2 sequence variant 3 (human)|UniProtKB:Q15796-1, Pro-445, CHEBI:29979 associated_with_disease_progression DOID:5672 large intestine cancer PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011378 20080301 PRO:CNA PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human) hSMAD2/iso:Long/AcPhos:1|UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007165 signal transduction PMID:17074756 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007165 signal transduction PMID:8752209|PMID:8980228|PMID:9346966 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025936 smad2 isoform Long phosphorylated 3 (human) hSMAD2/iso:Long/Phos:3|UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007165 signal transduction PMID:11027280 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse) mSMAD2/iso:Long/PhosUbiq:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148 acts_upstream_of_or_within GO:0007165 signal transduction PMID:15496141 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000025942 smad2 isoform Long phosphorylated 1 (mouse) mSMAD2/iso:Long/Phos:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007165 signal transduction PMID:11262418 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000000470 smad2 sequence variant R133C (human) hSMAD2/var:R133C|smad2 sequence variant 1 (human)|UniProtKB:Q15796-1, Arg-133, CHEBI:29950 acts_upstream_of_or_within GO:0007165 signal transduction PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011375 20080301 PRO:CNA PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007165 signal transduction PMID:12193595 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000025938 smad2 isoform Short phosphorylated 1 (human) hSMAD2/iso:Short/Phos:1|UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046 enables GO:0003677 DNA binding PMID:14701940|PMID:9873005 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human) hSMAD2/iso:Short/AcPhos:1|UniProtKB:Q15796-2, Lys-19, MOD:00394|Ser-435/Ser-437, MOD:00046 enables GO:0003677 DNA binding PMID:17074756 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human) hSMAD2/iso:Short/AcPhos:1|UniProtKB:Q15796-2, Lys-19, MOD:00394|Ser-435/Ser-437, MOD:00046 increased enables GO:0003700 DNA-binding transcription factor activity PR:000000656 PMID:17074756 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000025943 smad2 isoform Short phosphorylated 1 (mouse) mSMAD2/iso:Short/Phos:1|UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046 enables GO:0003700 DNA-binding transcription factor activity PMID:15630024 IDA NCBITaxon:10090 UniProtKB:Q62432-2 20080301 PRO:CNA PR:000025938 smad2 isoform Short phosphorylated 1 (human) hSMAD2/iso:Short/Phos:1|UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046 enables GO:0003700 DNA-binding transcription factor activity PMID:9873005 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 enables GO:0046332 SMAD binding PR:Q13485 PMID:12193595 IPI NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000025942 smad2 isoform Long phosphorylated 1 (mouse) mSMAD2/iso:Long/Phos:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046 enables GO:0046332 SMAD binding PR:P97471 PMID:11043574 IPI NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 enables GO:0046332 SMAD binding PR:Q13485 PMID:9311995 IPI NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025936 smad2 isoform Long phosphorylated 3 (human) hSMAD2/iso:Long/Phos:3|UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046 enables GO:0046332 SMAD binding PR:Q13485 PMID:11027280 IPI NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025937 smad2 isoform Long phosphorylated 4 (human) hSMAD2/iso:Long/Phos:4|UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046 located_in GO:0005737 cytoplasm PMID:10197981 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000045371 smad2 isoform Long unphosphorylated 1 (human) hSMAD2/iso:Long/UnPhos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291 located_in GO:0005737 cytoplasm PMID:15280432|PMID:17074053 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20151104 PRO:CNA PR:000025936 smad2 isoform Long phosphorylated 3 (human) hSMAD2/iso:Long/Phos:3|UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046 located_in GO:0005737 cytoplasm PMID:11027280 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse) mSMAD2/iso:Long located_in GO:0005737 cytoplasm PMID:14701940 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000025938 smad2 isoform Short phosphorylated 1 (human) hSMAD2/iso:Short/Phos:1|UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046 enables GO:0003712 transcription coregulator activity PMID:14701940|PMID:9873005 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 enables GO:0003712 transcription coregulator activity PMID:12193595 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000045371 smad2 isoform Long unphosphorylated 1 (human) hSMAD2/iso:Long/UnPhos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291 located_in GO:0005769 early endosome PMID:12356868 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20151104 PRO:CNA Note=When bound to PR:000002535 PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0006355 regulation of DNA-templated transcription PMID:12193595 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human) hSMAD2/iso:Long/AcPhos:1|UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0006355 regulation of DNA-templated transcription PMID:17074756 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0006355 regulation of DNA-templated transcription PMID:15690394|PMID:9689110 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025936 smad2 isoform Long phosphorylated 3 (human) hSMAD2/iso:Long/Phos:3|UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:11027280 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:12193595 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:9346966 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human) hSMAD2/iso:Short/AcPhos:1|UniProtKB:Q15796-2, Lys-19, MOD:00394|Ser-435/Ser-437, MOD:00046 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000025943 smad2 isoform Short phosphorylated 1 (mouse) mSMAD2/iso:Short/Phos:1|UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:15630024 IDA NCBITaxon:10090 UniProtKB:Q62432-2 20080301 PRO:CNA PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse) mSMAD2/iso:Long acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11557747 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000025942 smad2 isoform Long phosphorylated 1 (mouse) mSMAD2/iso:Long/Phos:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000045371 smad2 isoform Long unphosphorylated 1 (human) hSMAD2/iso:Long/UnPhos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209 IDA NCBITaxon:9609 UniProtKB:Q15796-1 20151104 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209|PMID:8980228 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025938 smad2 isoform Short phosphorylated 1 (human) hSMAD2/iso:Short/Phos:1|UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005 IDA NCBITaxon:9606 UniProtKB:Q15796-2 20080301 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228|PMID:9346966 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2|UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20101004 PRO:CNA PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse) mSMAD2/iso:Long/PhosUbiq:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148 NOT enables GO:0003713 transcription coactivator activity PMID:15496141 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046 enables GO:0003713 transcription coactivator activity PMID:9689110 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000025942 smad2 isoform Long phosphorylated 1 (mouse) mSMAD2/iso:Long/Phos:1|UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046 enables GO:0003713 transcription coactivator activity PMID:15282343 IDA NCBITaxon:10090 UniProtKB:Q62432-1 20080301 PRO:CNA PR:000025936 smad2 isoform Long phosphorylated 3 (human) hSMAD2/iso:Long/Phos:3|UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046 NOT enables GO:0003713 transcription coactivator activity PMID:11027280 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000000474 smad2 sequence variant 5 (human) hSMAD2/var:5|UniProtKB:Q15796-1, 2-343, 359-467 NOT enables GO:0003713 transcription coactivator activity PMID:8673135 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011376 20080301 PRO:CNA PR:000000470 smad2 sequence variant R133C (human) hSMAD2/var:R133C|smad2 sequence variant 1 (human)|UniProtKB:Q15796-1, Arg-133, CHEBI:29950 NOT enables GO:0003713 transcription coactivator activity PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011375 20080301 PRO:CNA PR:000000472 smad2 sequence variant P445H (human) hSMAD2/var:P445H|smad2 sequence variant 3 (human)|UniProtKB:Q15796-1, Pro-445, CHEBI:29979 NOT enables GO:0003713 transcription coactivator activity PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011378 20080301 PRO:CNA PR:000000473 smad2 sequence variant D450E (human) hSMAD2/var:D450E|smad2 sequence variant 4 (human)|UniProtKB:Q15796-1, Asp-450, CHEBI:29972 NOT enables GO:0003713 transcription coactivator activity PMID:8752209 EXP NCBITaxon:9606 UniProtKB_VAR:VAR_011379 20080301 PRO:CNA PR:000025937 smad2 isoform Long phosphorylated 4 (human) hSMAD2/iso:Long/Phos:4|UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046 NOT enables GO:0003713 transcription coactivator activity PMID:10197981 IDA NCBITaxon:9606 UniProtKB:Q15796-1 20080301 PRO:CNA PR:000045371 smad2 isoform Long unphosphorylated 1 (human) hSMAD2/iso:Long/UnPhos:1|UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291 enables GO:0005515 protein binding PMID:8980228 IPI NCBITaxon:9606 UniProtKB:Q15796-1 20151104 PRO:CNA