PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:000027814 cellular tumor antigen p53 isoform 1 phosphorylated 12 (human) hTP53/iso:1/Phos:12|p53-pSer15-pSer392|UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046 located_in GO:0005634 nucleus PMID:21317932 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD Kinase=NUAK1 [PR:O60285; PR:000011473]. NUAK1 gets activated upon phosphorylation by LKB1. PR:000035446 cellular tumor antigen p53 isoform 1 phosphorylated 1 (human) hTP53/iso:1/Phos:1|p53S15 (human)|UniProtKB:P04637-1, Ser-15, MOD:00046 located_in GO:0005634 nucleus PMID:11602639 EXP NCBITaxon:9606 UniProtKB:P04637-1 20090717 PRO:CL Note=HIV-1-Env-induced syncytium formation leads to apoptosis via a pathway that involves p53S15 phosphorylation by mTOR/FRAP. PR:000027808 cellular tumor antigen p53 isoform 1 methylated 3 (human) hTP53/iso:1/Me:3|p53-mLys372|UniProtKB:P04637-1, Lys-372, MOD:00663 located_in GO:0005634 nucleus PMID:15525938 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD PR:000027774 cellular tumor antigen p53 isoform 1 acetylated 1 (human) hTP53/iso:1/Ac:1|p53-acLys120|UniProtKB:P04637-1, Lys-120, MOD:00064 acts_upstream_of_or_within GO:0043065 positive regulation of apoptotic process PMID:17189187 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110920 PRO:PD Acetylase=hMOF. PR:000027808 cellular tumor antigen p53 isoform 1 methylated 3 (human) hTP53/iso:1/Me:3|p53-mLys372|UniProtKB:P04637-1, Lys-372, MOD:00663 acts_upstream_of_or_within GO:0045893 positive regulation of DNA-templated transcription PMID:15525938 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD PR:000027814 cellular tumor antigen p53 isoform 1 phosphorylated 12 (human) hTP53/iso:1/Phos:12|p53-pSer15-pSer392|UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046 acts_upstream_of_or_within GO:0045893 positive regulation of DNA-templated transcription PMID:21317932 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD Kinase=NUAK1 [PR:O60285; PR:000011473]. NUAK1 gets activated upon phosphorylation by LKB1. PR:000027812 cellular tumor antigen p53 isoform 1 acetylated 2 (human) hTP53/iso:1/Ac:2|p53-acLys382|UniProtKB:P04637-1, Lys-382, MOD:00064 acts_upstream_of_or_within GO:0045893 positive regulation of DNA-templated transcription PMID:20228809 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD Acetylace=Acetyltransferase EP300 [PR:Q09472; PR:000007102]. PR:000027833 cellular tumor antigen p53 isoform 1 phosphorylated 9 (human) hTP53/iso:1/Phos:9|p53-pSer15-pSer37|UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046 acts_upstream_of_or_within GO:0010468 regulation of gene expression PMID:14712210 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD PR:000027839 cellular tumor antigen p53 isoform 1 phosphorylated 11 (human) hTP53/iso:1/Phos:11|p53-pSer183-pSer269-pThr284|UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047 acts_upstream_of_or_within GO:0010629 negative regulation of gene expression PMID:20959462 EXP NCBITaxon:9606 UniProtKB:P04637-1 20111029 PRO:PD Kinase=AURKB [PR:Q96GD4] PR:000036624 cellular tumor antigen p53 isoform 1 phosphorylated 2 (human) hTP53/iso:1/Phos:2|UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046 acts_upstream_of_or_within GO:0006915 apoptotic process PMID:15642743 EXP NCBITaxon:9606 UniProtKB:P04637-1 20090717 PRO:CL Note=This form is induced by HIV gp120/gp41. PR:000035446 cellular tumor antigen p53 isoform 1 phosphorylated 1 (human) hTP53/iso:1/Phos:1|p53S15 (human)|UniProtKB:P04637-1, Ser-15, MOD:00046 acts_upstream_of_or_within GO:0006915 apoptotic process PMID:11602639 EXP NCBITaxon:9606 UniProtKB:P04637-1 20090717 PRO:CL Note=HIV-1-Env-induced syncytium formation leads to apoptosis via a pathway that involves p53S15 phosphorylation by mTOR/FRAP. PR:000027810 cellular tumor antigen p53 isoform 1 methylated 4 (human) hTP53/iso:1/Me:4|p53-mLys370|UniProtKB:P04637-1, Lys-370, MOD:00663 acts_upstream_of_or_within GO:0045892 negative regulation of DNA-templated transcription PMID:17108971 EXP NCBITaxon:9606 UniProtKB:P04637-1 20110929 PRO:PD Lysine methyltransferase, SMYD2 [PR:Q9NRG4]. PR:000027766 cellular tumor antigen p53 isoform 1 dimethylated 1 (human) hTP53/iso:1/Me2:1|p53K382me2|UniProtKB:P04637-1, Lys-382, MOD:00084 enables GO:0005515 protein binding PR:Q12888 PMID:18840612 IPI NCBITaxon:9606 UniProtKB:P04637-1 20110919 PRO:PD PR:P04637-1 cellular tumor antigen p53 isoform 1 (human) hTP53/iso:1 enables GO:0005515 protein binding PR:O60566 PMID:17671183 IPI NCBITaxon:9606 UniProtKB:P04637-1 20121105 PRO:KER Timing=metaphase and spindle depolymerization (nocodazole) PR:P04637-1 cellular tumor antigen p53 isoform 1 (human) hTP53/iso:1 enables GO:0005515 protein binding PR:O43683 PMID:19252416 IPI NCBITaxon:9606 UniProtKB:P04637-1 20121105 PRO:KER Timing=metaphase and spindle depolymerization (nocodazole) PR:000036624 cellular tumor antigen p53 isoform 1 phosphorylated 2 (human) hTP53/iso:1/Phos:2|UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046 enables GO:0005515 protein binding PR:000003109 PMID:15642743 IPI NCBITaxon:9606 UniProtKB:P04637-1 20090717 PRO:CL Note=Induced by HIV gp120/gp41.