PRO_ID	Object_term	Object_syny	Modifier	Relation	Ontology_ID	Ontology_term	Relative_to	Interaction_with	Evidence_source	Evidence_code	Taxon	Inferred_from	DB_ID	Date	Assigned_by	Comment
PR:000036077	activated TLR4 complex (mouse)	LY96:LPS:TLR4 complex (mouse)|MD2:LPS:TLR4 complex (mouse)|mTLR4actv|TLR4MD2LPS complex dimer (mouse)		acts_upstream_of_or_within	GO:0002756	MyD88-independent toll-like receptor signaling pathway			PMID:23565187	EXP	NCBITaxon:10090			20140718	TLR:AMM	
PR:000037474	activated TLR4 complex (chicken)	chick-(LY96:LPS:TLR4)|chick-TLR4actv|LY96:LPS:TLR4 complex (chicken)|MD2:LPS:TLR4 (chicken)		located_in	GO:0005886	plasma membrane			Reactome:REACT_25442	EXP	NCBITaxon:9031		Reactome:REACT_25442	20140514	PRO:CNA	
PR:000037474	activated TLR4 complex (chicken)	chick-(LY96:LPS:TLR4)|chick-TLR4actv|LY96:LPS:TLR4 complex (chicken)|MD2:LPS:TLR4 (chicken)		acts_upstream_of_or_within	GO:0034142	toll-like receptor 4 signaling pathway			PMID:18768894	EXP	NCBITaxon:9031		Reactome:REACT_25442	20140514	PRO:CNA	
PR:000037474	activated TLR4 complex (chicken)	chick-(LY96:LPS:TLR4)|chick-TLR4actv|LY96:LPS:TLR4 complex (chicken)|MD2:LPS:TLR4 (chicken)		acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process			PMID:24034933	EXP	NCBITaxon:9031			20140718	PRO:CNA	Evidence=ECO:0000305, PMID:24034933 shows the increase of TLR4  in cell surface in response to LPS in viral infection. It also shows the production of NO as a downstream effect. Evidence=ECO:0000305, the complex with MD2 has been inferred by curator based on PMID:18768894. Note=In response to laryngotracheitis virus.
PR:000037474	activated TLR4 complex (chicken)	chick-(LY96:LPS:TLR4)|chick-TLR4actv|LY96:LPS:TLR4 complex (chicken)|MD2:LPS:TLR4 (chicken)		acts_upstream_of_or_within	GO:0051607	defense response to virus			PMID:24034933	EXP	NCBITaxon:9031			20140718	PRO:CNA	Evidence=ECO:0000305, PMID:24034933 shows the increase of TLR4  in cell surface in response to LPS in viral infection. It also shows the production of NO as a downstream effect. Evidence=ECO:0000305, the complex with MD2 has been inferred by curator based on PMID:18768894. Note=In response to laryngotracheitis virus.