PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0004672 protein kinase activity PMID:10198256 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:O43684 PMID:10198256|PMID:15525512 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Note=Interaction observed through out the cell cycle. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:O60566 PMID:11792804 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Note=Interaction observed in nocodazole. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:P04637-1 PMID:19252416 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:P25054 BioGRID:BG-302960 IPI NCBITaxon:9606 UniProtKB:O43683 20130103 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:P53350 BioGRID:BG-718371 IPI NCBITaxon:9606 UniProtKB:O43683 20130103 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:Q8NG31 BioGRID:BG-723200 IPI NCBITaxon:9606 UniProtKB:O43683 20130103 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 enables GO:0005515 protein binding PR:Q9Y6D9 PMID:10198256 IPI NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 located_in GO:0000776 kinetochore PMID:20624902 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Timing=Mitosis (prophase, prometaphase, metaphase) and spindle disruption (nocodazole). Localization is increased by PR:Q9NQS7. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 located_in GO:0000939 inner kinetochore PMID:11792804 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 located_in GO:0000940 outer kinetochore PMID:11792804|PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0007059 chromosome segregation PMID:16580887 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0007062 sister chromatid cohesion PMID:16580887 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:19252416 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0043069 negative regulation of programmed cell death PMID:20057499 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16580887 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:P30153. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:Q5FBB7. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=phospho-Thr-3-Histone H3. PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human) BUB1|BUB1A (human)|BUB1L|hBUB1 acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950 EXP NCBITaxon:9606 UniProtKB:O43683 20121105 PRO:KER Target=PR:Q96GD4.