PRO_ID Object_term Object_syny Modifier Relation Ontology_ID Ontology_term Relative_to Interaction_with Evidence_source Evidence_code Taxon Inferred_from DB_ID Date Assigned_by Comment PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:000035449 PMID:11030144 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:000035450 PMID:11030144 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:O15350 BioGRID:BG-717441 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:O15379 MINT:MINT-7302235 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:O43683 PMID:11792804 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:O43684 PMID:20016069 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Note=Interaction occurs under nocodazole treatment. Kinetochore localization increased in this condition. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:O76070 BioGRID:BG-253351 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:O95997 BioGRID:BG-721860 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:P04049 PMID:20703093 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:P04637-1 PMID:17671183 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Timing=spindle depolymerization (nocodazole). PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:P09874 BioGRID:BG-480411 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:P25054 BioGRID:BG-302963 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:P51587 PMID:10749118 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:P63010 BioGRID:BG-283405 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q02224 PMID:17785528 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q12834 PMID:11030144|PMID:20624902 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q13042 PMID:11030144 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q13257 PMID:20624902 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Timing=interphase and mitosis. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q13547 MINT:MINT-7302173 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q15013 BioGRID:BG-719779 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q8NG31 BioGRID:BG-697203 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q92769 MINT:MINT-7302197 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q92831 MINT:MINT-7299740 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q96GD4 BioGRID:BG-717911 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q96IF1 BioGRID:BG-717913 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q9H081 BioGRID:BG-715437 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q9H4B4 PMID:15190214 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q9NQS7 PMID:16760428|PMID:17785528 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q9UJX3 BioGRID:BG-316229 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0005515 protein binding PR:Q9UJX5 BioGRID:BG-682429 IPI NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0016301 kinase activity PMID:11030144 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:000035369 PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 enables GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:000035371 PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 located_in GO:0000776 kinetochore PMID:12719470|PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Timing=Mitosis (prophase, prometaphase, metaphase). Kinetochore localization increased by O43683 (Bub1). PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 located_in GO:0000922 spindle pole PMID:15190214 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Timing=metaphase. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 located_in GO:0000939 inner kinetochore PMID:11792804 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 located_in GO:0000940 outer kinetochore PMID:11792804 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 located_in GO:0005737 cytoplasm PMID:10749118 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Timing=interphase. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0006469 negative regulation of protein kinase activity PMID:15592459 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:000035365. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:11030144 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0031647 regulation of protein stability PMID:17671183 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:P04637-1. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0051310 metaphase chromosome alignment PMID:12719470|PMID:15592459 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:000035369. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:000035371. PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 acts_upstream_of_or_within GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER PR:O60566 mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) BUB1B|BUBR1|hBUB1B|hBUBR1|MAD3/BUB1-related protein kinase (human)|MAD3L|mitotic checkpoint kinase MAD3L (human)|protein SSK1 (human)|SSK1 NOT acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 EXP NCBITaxon:9606 UniProtKB:O60566 20121105 PRO:KER Target=PR:Q9NQS7. Timing=Mitosis.